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How Much Does HIV Positivity Affect the Presence of Oral HPV? A Molecular Epidemiology Survey

Author

Listed:
  • Giuseppa Visalli

    (Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy)

  • Angela Di Pietro

    (Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy)

  • Monica Currò

    (Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy)

  • Marianna Pruiti Ciarello

    (Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy)

  • Flavia D’Andrea

    (Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, 98122 Messina, Italy)

  • Giuseppe Nunnari

    (Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, 98122 Messina, Italy)

  • Giovanni Francesco Pellicanò

    (Department of Human Pathology of the Adult and the Developmental Age “G. Barresi”, Unit of Infectious Diseases, University of Messina, 98122 Messina, Italy)

  • Alessio Facciolà

    (Department of Biomedical and Dental Sciences and MorphoFunctional Imaging, University of Messina, 98122 Messina, Italy)

Abstract

HIV-positive people showed a high oral prevalence of HPV-DNA and have a greater incidence of head and neck carcinomas compared to general population. We performed a molecular survey evaluating the presence of HPV-DNA in saliva of HIV-positive and HIV-negative subjects in order to quantify the risk represented by HIV-positivity. The sample was made up by 102 subjects: 40 HIV-positive, 32 HIV-negative with sexual risk behaviors (SRB) and 30 HIV-negative without risk factors. DNA was extracted from cellular pellets and HPV detection and genotyping were performed by PCR assays. In the HIV-positive group (of which 58.3% declared SRB) 33.33% of the sample were HPV-positive (33.33% to high-risk genotypes, 25.0% to low-risk genotypes and 41.66% to other genotypes). In the HIV-negative SRB group, HPV-positive subjects were 37.04% (60.0% to high risk genotypes, 20.0% to low risk genotypes, and 20.0% to other genotypes). Finally, in the control group, the HPV-positive subjects were 7.14% (50% to high-risk genotypes and 50% to low-risk genotypes). In the HIV group, concerning the HPV positivity, there was no significant difference between subjects with and without SRBs. In summary, we found a high oral HPV-DNA detection in HIV+ group, showing a strong relationship between HIV and HPV.

Suggested Citation

  • Giuseppa Visalli & Angela Di Pietro & Monica Currò & Marianna Pruiti Ciarello & Flavia D’Andrea & Giuseppe Nunnari & Giovanni Francesco Pellicanò & Alessio Facciolà, 2021. "How Much Does HIV Positivity Affect the Presence of Oral HPV? A Molecular Epidemiology Survey," IJERPH, MDPI, vol. 18(17), pages 1-12, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:17:p:8999-:d:622594
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    References listed on IDEAS

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    1. Eleanor M King & Soonita Oomeer & Richard Gilson & Andrew Copas & Simon Beddows & Kate Soldan & Mark Jit & W John Edmunds & Pam Sonnenberg, 2016. "Oral Human Papillomavirus Infection in Men Who Have Sex with Men: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-15, July.
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