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Association of Family History with the Development of Breast Cancer: A Cohort Study of 129,374 Women in KoGES Data

Author

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  • Hyo Geun Choi

    (Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Korea)

  • Jung Ho Park

    (Department of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Korea)

  • Yeon Ju Choi

    (Research Cooperation Center, Hallym University, Chuncheon 24252, Korea)

  • Yong Joon Suh

    (Department of Breast and Endocrine Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Korea)

Abstract

Background: Breast cancer is the most common cancer among women. The Korean Genome and Epidemiology Study (KoGES) is a large cohort study that is available to the public. Using this large cohort study, we aimed to unravel the relationship between breast cancer development and a family history of breast cancer in Korea. Methods: This cohort study relied on data from the KoGES from 2001 through 2013. A total of 211,725 participants were screened. Of these, 129,374 women were evaluated. They were divided into two groups, including participants with and without breast cancer. A logistic regression model was used to retrospectively analyze the odds ratio of breast cancer history in families of women with and without breast cancer. Results: Of 129,374 women, 981 had breast cancer. The breast cancer group had more mothers and siblings with histories of breast cancer ( p < 0.001). A history of breast cancer in the participant’s mother resulted in an odds ratio of 3.12 (1.75–5.59), and a history of breast cancer in the participant’s sibling resulted in an odds ratio of 2.63 (1.85–3.74). There was no interaction between the history of maternal breast cancer and the history of sibling breast cancer. Based on the subgroup analysis, family history was a stronger factor in premenopausal women than in menopausal and postmenopausal women. Conclusions: A family history of breast cancer is a significant risk factor for breast cancer in Korea. Premenopausal women with a maternal history of breast cancer are of particular concern. Intensive screening and risk-reducing strategies should be considered for this vulnerable subpopulation.

Suggested Citation

  • Hyo Geun Choi & Jung Ho Park & Yeon Ju Choi & Yong Joon Suh, 2021. "Association of Family History with the Development of Breast Cancer: A Cohort Study of 129,374 Women in KoGES Data," IJERPH, MDPI, vol. 18(12), pages 1-9, June.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:12:p:6409-:d:574362
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    1. Christopher J. Lord & Alan Ashworth, 2012. "The DNA damage response and cancer therapy," Nature, Nature, vol. 481(7381), pages 287-294, January.
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