IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i8p2946-d350001.html
   My bibliography  Save this article

Residential Radon Exposure and Cigarette Smoking in Association with Lung Cancer: A Matched Case-Control Study in Korea

Author

Listed:
  • Eung Joo Park

    (Department of Precision Medicine & Biostatistics, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
    Center of Biomedical Data Science, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
    Eung Joo Park and Hokyou Lee contributed equally to this work as first authors.)

  • Hokyou Lee

    (Department of Preventive Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
    Eung Joo Park and Hokyou Lee contributed equally to this work as first authors.)

  • Hyeon Chang Kim

    (Department of Preventive Medicine, Yonsei University College of Medicine, Seoul 03722, Korea
    Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul 03722, Korea)

  • Seung Soo Sheen

    (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon 16499, Korea)

  • Sang Baek Koh

    (Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea)

  • Ki Soo Park

    (Department of Preventive Medicine, School of Medicine, Gyeongsang National University, Jinju 52828, Korea)

  • Nam Han Cho

    (Department of Preventive Medicine, Ajou University School of Medicine, Suwon 16499, Korea)

  • Cheol-Min Lee

    (Department of Chemical and Biological Engineering, Seokyeong University, Seoul 02713, Korea)

  • Dae Ryong Kang

    (Department of Precision Medicine & Biostatistics, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
    Center of Biomedical Data Science, Yonsei University Wonju College of Medicine, Wonju 26426, Korea)

Abstract

Residential radon exposure and cigarette smoking are the two most important risk factors for lung cancer. The combined effects thereof were evaluated in a multi-center matched case-control study in South Korea. A total of 1038 participants were included, comprising 519 non-small cell lung cancer cases and 519 age- and sex- matched community-based controls. Residential radon levels were measured for all participants. Multivariate logistic regression was used to calculate odds ratios (OR) for lung cancer according to radon exposure (high ≥ 100 Bq/m 3 vs. low < 100 Bq/m 3 ), smoking status, and combinations of the two after adjusting for age, sex, indoor hours, and other housing information. The median age of the participants was 64 years, and 51.3% were women. The adjusted ORs (95% confidence intervals [CIs]) for high radon and cigarette smoking were 1.56 (1.03–2.37) and 2.53 (1.60–3.99), respectively. When stratified according to combinations of radon exposure and smoking status, the adjusted ORs (95% CIs) for lung cancer in high-radon non-smokers, low-radon smokers, and high-radon smokers were 1.40 (0.81–2.43), 2.42 (1.49–3.92), and 4.27 (2.14–8.52), respectively, with reference to low-radon non-smokers. Both residential radon and cigarette smoking were associated with increased odds for lung cancer, and the difference in ORs according to radon exposure was much greater in smokers than in non-smokers.

Suggested Citation

  • Eung Joo Park & Hokyou Lee & Hyeon Chang Kim & Seung Soo Sheen & Sang Baek Koh & Ki Soo Park & Nam Han Cho & Cheol-Min Lee & Dae Ryong Kang, 2020. "Residential Radon Exposure and Cigarette Smoking in Association with Lung Cancer: A Matched Case-Control Study in Korea," IJERPH, MDPI, vol. 17(8), pages 1-9, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2946-:d:350001
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/8/2946/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/8/2946/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Ji Hyun Park & Cheol Min Lee & Hyun Young Lee & Dae Ryong Kang, 2018. "Estimation of Seasonal Correction Factors for Indoor Radon Concentrations in Korea," IJERPH, MDPI, vol. 15(10), pages 1-13, October.
    2. Ladislav Tomasek, 2013. "Lung Cancer Risk from Occupational and Environmental Radon and Role of Smoking in Two Czech Nested Case-Control Studies," IJERPH, MDPI, vol. 10(3), pages 1-17, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Le Thi Nhu Ngoc & Duckshin Park & Young-Chul Lee, 2022. "Human Health Impacts of Residential Radon Exposure: Updated Systematic Review and Meta-Analysis of Case–Control Studies," IJERPH, MDPI, vol. 20(1), pages 1-19, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mohammademad Adelikhah & Amin Shahrokhi & Morteza Imani & Stanislaw Chalupnik & Tibor Kovács, 2020. "Radiological Assessment of Indoor Radon and Thoron Concentrations and Indoor Radon Map of Dwellings in Mashhad, Iran," IJERPH, MDPI, vol. 18(1), pages 1-15, December.
    2. Ji Hyun Park & Cheol Min Lee & Dae Ryong Kang, 2019. "A Deterministic Model for Estimating Indoor Radon Concentrations in South Korea," IJERPH, MDPI, vol. 16(18), pages 1-8, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2946-:d:350001. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.