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Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort

Author

Listed:
  • Ainara Andiarena

    (Faculty of Psychology of the University of the Basque Country, 20018 San Sebastian, Spain
    Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain)

  • Amaia Irizar

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain)

  • Amaia Molinuevo

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain)

  • Nerea Urbieta

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain)

  • Izaro Babarro

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain)

  • Mikel Subiza-Pérez

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain)

  • Loreto Santa-Marina

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain
    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, C/Monforte de Lemos 3-5, 28029 Madrid, Spain
    Health Department of the Basque Government, Sub-directorate of Public Health of Gipuzkoa, 20013 San Sebastian, Spain)

  • Jesús Ibarluzea

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain
    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, C/Monforte de Lemos 3-5, 28029 Madrid, Spain
    Health Department of the Basque Government, Sub-directorate of Public Health of Gipuzkoa, 20013 San Sebastian, Spain)

  • Aitana Lertxundi

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Doctor Begiristain, s/n, 20014 San Sebastian, Spain
    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, C/Monforte de Lemos 3-5, 28029 Madrid, Spain)

Abstract

Background : Manganese (Mn) is an essential micronutrient for humans, the diet being the main source of exposure. Some epidemiological studies describe a negative association between prenatal Mn and later neuropsychological development, but results are inconsistent. The aim of this study was to explore the association between prenatal Mn exposure and neuropsychological development assessed at 4 years of age. Methods : Study subjects were 304 mother-child pairs from the Gipuzkoa cohort of the INMA (Environment and Childhood) Project. Mn was measured in newborns’ hair. Children’s neuropsychological development was assessed at 4 years of age using the McCarthy Scales of Children’s Abilities. Multivariate linear regression models were built. Stratified analysis by sex was performed. Generalized additive models were used to assess the shape of the relation. Results : The median Mn concentration in newborns’ hair was 0.42 μg/g (95% CI = 0.38, 0.46). The association between Mn levels and the neuropsychological development was not statistically significant for the general cognitive scale (β [95% CI] = 0.36 [−5.23, 5.95]), motor scale (β [95% CI] = 1.9 [−3.74, 7.55]) or any of the other outcomes. No sex-specific pattern was found. The best shape describing the relationship was linear for all the scales. Conclusion : Our results suggest that prenatal Mn concentrations measured in newborns’ hair do not affect cognitive or motor development at 4 years of age in boys or in girls at the observed Mn levels.

Suggested Citation

  • Ainara Andiarena & Amaia Irizar & Amaia Molinuevo & Nerea Urbieta & Izaro Babarro & Mikel Subiza-Pérez & Loreto Santa-Marina & Jesús Ibarluzea & Aitana Lertxundi, 2020. "Prenatal Manganese Exposure and Long-Term Neuropsychological Development at 4 Years of Age in a Population-Based Birth Cohort," IJERPH, MDPI, vol. 17(5), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1665-:d:328265
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    References listed on IDEAS

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    1. Barreto, Florencia Belén & Sánchez de Miguel, Manuel & Ibarluzea, Jesús & Andiarena, Ainara & Arranz, Enrique, 2017. "Family context and cognitive development in early childhood: A longitudinal study," Intelligence, Elsevier, vol. 65(C), pages 11-22.
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