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Chemical Characterization of Seasonal PM 2.5 Samples and Their Cytotoxicity in Human Lung Epithelial Cells (A549)

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  • Ao Di

    (Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, Nanjing 210044, China)

  • Yun Wu

    (Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, Nanjing 210044, China)

  • Mindong Chen

    (Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, Nanjing 210044, China)

  • Dongyang Nie

    (School of Atmospheric Sciences, Nanjing University, Nanjing 210023, China)

  • Xinlei Ge

    (Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, Nanjing 210044, China)

Abstract

In order to study the toxicity of fine particulate matter (PM 2.5 ) sourced from different seasons on human health, we collected PM 2.5 samples quarterly from March 2016 to February 2017 in Nanjing, China. The component analysis results showed that high proportions of water-soluble organic carbon (WSOC), SO 4 2− , Ca 2+ and Mg 2+ were found in the summer samples, while high proportions of NO 3 − , NH 4 + and heavy metals were observed in the spring and winter samples. Then human lung epithelial cells (A549) were exposed to the PM 2.5 samples. The toxicological results indicated that reactive oxygen species (ROS) production in the spring and winter samples was higher than that in the summer and fall samples, which was related to the contribution of some heavy metals and inorganic ions (e.g., Pb and NO 3 − ). However, the apoptosis rates of the cells showed the opposite seasonal changes as what the ROS did, which might be caused by the higher WSOC content in the summer. In addition, regression analysis also showed the importance of the PM 2.5 components in ROS production and apoptosis. Particularly, Zn had the strongest correlation with ROS production (R = 0.863) and cell apoptosis (R = 0.675); thus, the specific toxicity of Zn in PM 2.5 deserves further investigation. Our results could be beneficial for assessing the health risks and controlling the toxic components of PM 2.5 in Nanjing.

Suggested Citation

  • Ao Di & Yun Wu & Mindong Chen & Dongyang Nie & Xinlei Ge, 2020. "Chemical Characterization of Seasonal PM 2.5 Samples and Their Cytotoxicity in Human Lung Epithelial Cells (A549)," IJERPH, MDPI, vol. 17(12), pages 1-13, June.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:12:p:4599-:d:376712
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    References listed on IDEAS

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    1. Pascal Meier & Andrew Finch & Gerard Evan, 2000. "Apoptosis in development," Nature, Nature, vol. 407(6805), pages 796-801, October.
    2. Longfei Guan & Wei Rui & Ru Bai & Wei Zhang & Fang Zhang & Wenjun Ding, 2016. "Effects of Size-Fractionated Particulate Matter on Cellular Oxidant Radical Generation in Human Bronchial Epithelial BEAS-2B Cells," IJERPH, MDPI, vol. 13(5), pages 1-14, May.
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    Cited by:

    1. Yun Wu & Mei Wang & Shaojuan Luo & Yunfeng Gu & Dongyang Nie & Zhiyang Xu & Yue Wu & Mindong Chen & Xinlei Ge, 2020. "Comparative Toxic Effects of Manufactured Nanoparticles and Atmospheric Particulate Matter in Human Lung Epithelial Cells," IJERPH, MDPI, vol. 18(1), pages 1-12, December.

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