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Exposure to Atmospheric Ultrafine Particles Induces Severe Lung Inflammatory Response and Tissue Remodeling in Mice

Author

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  • Yara Saleh

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Sébastien Antherieu

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Romain Dusautoir

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Laurent Y. Alleman

    (Département Sciences de l’Atmosphère et Génie de l’Environnement (SAGE), IMT Lille Douai, Université de Lille, 59000 Lille, France)

  • Jules Sotty

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Corentin De Sousa

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Anne Platel

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Esperanza Perdrix

    (Département Sciences de l’Atmosphère et Génie de l’Environnement (SAGE), IMT Lille Douai, Université de Lille, 59000 Lille, France)

  • Véronique Riffault

    (Département Sciences de l’Atmosphère et Génie de l’Environnement (SAGE), IMT Lille Douai, Université de Lille, 59000 Lille, France)

  • Isabelle Fronval

    (Département Sciences de l’Atmosphère et Génie de l’Environnement (SAGE), IMT Lille Douai, Université de Lille, 59000 Lille, France)

  • Fabrice Nesslany

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Ludivine Canivet

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Guillaume Garçon

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

  • Jean-Marc Lo-Guidice

    (EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France)

Abstract

Exposure to particulate matter (PM) is leading to various respiratory health outcomes. Compared to coarse and fine particles, less is known about the effects of chronic exposure to ultrafine particles, despite their higher number and reactivity. In the present study, we performed a time-course experiment in mice to better analyze the lung impact of atmospheric ultrafine particles, with regard to the effects induced by fine particles collected on the same site. Trace element and PAH analysis demonstrated the almost similar chemical composition of both particle fractions. Mice were exposed intranasally to FF or UFP according to acute (10, 50 or 100 µg of PM) and repeated (10 µg of PM 3 times a week during 1 or 3 months) exposure protocols. More particle-laden macrophages and even greater chronic inflammation were observed in the UFP-exposed mice lungs. Histological analyses revealed that about 50% of lung tissues were damaged in mice exposed to UFP for three months versus only 35% in FF-exposed mice. These injuries were characterized by alveolar wall thickening, macrophage infiltrations, and cystic lesions. Taken together, these results strongly motivate the update of current regulations regarding ambient PM concentrations to include UFP and limit their emission.

Suggested Citation

  • Yara Saleh & Sébastien Antherieu & Romain Dusautoir & Laurent Y. Alleman & Jules Sotty & Corentin De Sousa & Anne Platel & Esperanza Perdrix & Véronique Riffault & Isabelle Fronval & Fabrice Nesslany , 2019. "Exposure to Atmospheric Ultrafine Particles Induces Severe Lung Inflammatory Response and Tissue Remodeling in Mice," IJERPH, MDPI, vol. 16(7), pages 1-18, April.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:7:p:1210-:d:219986
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    References listed on IDEAS

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    1. Richard W. Baldauf & Robert B. Devlin & Peter Gehr & Robert Giannelli & Beth Hassett-Sipple & Heejung Jung & Giorgio Martini & Joseph McDonald & Jason D. Sacks & Katherine Walker, 2016. "Ultrafine Particle Metrics and Research Considerations: Review of the 2015 UFP Workshop," IJERPH, MDPI, vol. 13(11), pages 1-21, October.
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    Cited by:

    1. Vesna Viher Hrženjak & Andreja Kukec & Ivan Eržen & Dalibor Stanimirović, 2020. "Effects of Ultrafine Particles in Ambient Air on Primary Health Care Consultations for Diabetes in Children and Elderly Population in Ljubljana, Slovenia: A 5-Year Time-Trend Study," IJERPH, MDPI, vol. 17(14), pages 1-19, July.

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