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The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study

Author

Listed:
  • Hung-Jui Hsu

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    These authors contributed equally to the work.)

  • Chia-Yi Lee

    (Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan 717, Taiwan
    These authors contributed equally to the work.)

  • Shih-Chun Chao

    (Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 300, Taiwan
    Department of Optometry, Central Taiwan University of Science and Technology, Taichung 406, Taiwan)

  • Chan-Wei Nien

    (Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Optometry, Central Taiwan University of Science and Technology, Taichung 406, Taiwan)

  • Shih-Hao Tzeng

    (Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333, Taiwan)

  • Jing-Yang Huang

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Tai-Chuan Ko

    (Department of Optometry, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Hung-Yu Lin

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Optometry, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan
    Department of Optometry, Chung Shan Medical University, Taichung 402, Taiwan)

Abstract

The aim of the present study was to survey the relationship between central serous chorioretinopathy (CSC) and several cardiovascular diseases (CVDs) with different severities using the National Health Insurance Research Database. A retrospective cohort study was conducted. Subjects with CSC were enrolled according to the relevant diagnostic codes, and an age- and gender-matched population was used as the control group with a 1:4 ratio. The main outcome being considered was the development of CVD after CSC exposure. Cox proportional hazard regression was applied to calculate the adjusted hazard ratio (aHR) of CSC and CVD of different types. A total of 2865 patients that were diagnosed with CSC were enrolled in the study group, while another 11,460 non-CSC subjects were selected as the control group. There were 171 events of CVD which occurred in the study group, while another 557 cases were found in the control group. No significant differences were observed among the CVD cases between the study and control group, whether they had an acute or chronic form, according to the aHR. In the subgroup analysis, there was a significantly higher risk of CVD development in the male population aged from 40 to 59 years (aHR: 1.351, confidence interval (CI): 1.063–1.716), which was mainly due to the higher risk of mild CVD (aHR: 1.391, CI: 1.062–1.822). On the contrary, there was no significant difference in CVD development in any of the age subgroups of the female population. In conclusion, the existence of CSC is correlated with a higher rate of chronic CVD occurrence in the middle-aged male population.

Suggested Citation

  • Hung-Jui Hsu & Chia-Yi Lee & Shih-Chun Chao & Chan-Wei Nien & Shih-Hao Tzeng & Jing-Yang Huang & Tai-Chuan Ko & Shun-Fa Yang & Hung-Yu Lin, 2019. "The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study," IJERPH, MDPI, vol. 16(24), pages 1-10, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:24:p:5099-:d:297789
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    References listed on IDEAS

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    1. Hsiang-Wen Chien & Pei-Hsuan Wu & Kai Wang & Chi-Chin Sun & Jing-Yang Huang & Shun-Fa Yang & Hung-Chi Chen & Chia-Yi Lee, 2019. "Increased Incidence of Glaucoma in Sensorineural Hearing Loss: A Population-Based Cohort Study," IJERPH, MDPI, vol. 16(16), pages 1-10, August.
    2. Partha Dutta & Gabriel Courties & Ying Wei & Florian Leuschner & Rostic Gorbatov & Clinton S. Robbins & Yoshiko Iwamoto & Brian Thompson & Alicia L. Carlson & Timo Heidt & Maulik D. Majmudar & Felix L, 2012. "Myocardial infarction accelerates atherosclerosis," Nature, Nature, vol. 487(7407), pages 325-329, July.
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    Cited by:

    1. Domenico Di Raimondo & Gaia Musiari & Giuliana Rizzo & Edoardo Pirera & Salvatore Santo Signorelli, 2022. "New Insights in Prevention and Treatment of Cardiovascular Disease," IJERPH, MDPI, vol. 19(4), pages 1-7, February.

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