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Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men

Author

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  • Xiuxia Song

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China
    The authors contributed equally to the publication.)

  • Maohua Miao

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China
    The authors contributed equally to the publication.)

  • Xiaoyu Zhou

    (Shanghai Tongshu Biotechnology Co., Ltd., Shanghai 200237, China)

  • Dekun Li

    (Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente Northern California, Oakland CA 94612, USA)

  • Youping Tian

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China
    School of Public Health, Fudan University, Shanghai 200237, China)

  • Hong Liang

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China)

  • Runsheng Li

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China)

  • Wei Yuan

    (Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200237, China)

Abstract

Exposure to bisphenol A (BPA) has been shown to impact human sperm quality. The epigenetic mechanisms underlying the effect remain unknown. The acetylcholinesterase (ACHE) gene is a sperm-expressed gene encoding the acetylcholine hydrolyzing enzyme acetylcholinesterase and participates in the apoptosis of cells, including sperm. This study aimed to examine whether BPA exposure is associated with the hydroxymethylation level of the sperm ACHE gene. A total of 157 male factory workers were studied, among whom 74 had BPA exposure in the workplace (BPA exposure group) and 83 had no BPA exposure in the workplace (control group). Urine samples were collected for BPA measurement and semen samples were collected to assay for ACHE hydroxymethylation. Sperm ACHE hydroxymethylation level was higher in the BPA exposure group ( p = 0.041) compared to the control group. When subjects were categorized according to tertiles of detected BPA level, higher ACHE hydroxymethylation levels were observed for the lowest, middle, and top tertiles compared to those with BPA below the limit of detection (LOD). In a linear regression analysis adjusted for confounders, a positive linear association between urine BPA concentration and 5-hydroxymethylcytosine (5hmC) rate of the sperm ACHE gene was observed, although the association did not reach statistical significance in all categories after being stratified by the BPA tertile. In conclusion, 5hmC of the sperm ACHE gene was positively associated with BPA exposure, which may provide supportive evidence for BPA’s effects on male fertility or other health endpoints.

Suggested Citation

  • Xiuxia Song & Maohua Miao & Xiaoyu Zhou & Dekun Li & Youping Tian & Hong Liang & Runsheng Li & Wei Yuan, 2019. "Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men," IJERPH, MDPI, vol. 16(1), pages 1-12, January.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:1:p:152-:d:195718
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    References listed on IDEAS

    as
    1. Maohua Miao & Wei Yuan & Fen Yang & Hong Liang & Zhijun Zhou & Runsheng Li & Ersheng Gao & De-Kun Li, 2015. "Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers," IJERPH, MDPI, vol. 12(10), pages 1-11, October.
    2. Guergana Mileva & Stephanie L. Baker & Anne T.M. Konkle & Catherine Bielajew, 2014. "Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior," IJERPH, MDPI, vol. 11(7), pages 1-25, July.
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