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Association between the Occurrence of Primary Hypothyroidism and the Exposure of the Population Near to Industrial Pollutants in São Paulo State, Brazil

Author

Listed:
  • Maria Angela Zaccarelli-Marino

    (Internal Medicine Department, Endocrinology Service, ABC Medical School, Foundation, Santo André, SP 09060-870, Brazil)

  • Rudá Alessi

    (Internal Medicine Department, ABC Medical School Foundation, Santo André, SP 09060-870, Brazil)

  • Thalles Zaccarelli Balderi

    (Internal Medicine Service, Santa Paula Hospital, São Paulo, SP 04556-100, Brazil)

  • Marco Antonio Garcia Martins

    (Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA)

Abstract

Background: Environmental agents interfere with thyroid function at multiple levels. This study was to investigate the association between pollutant concentrations and the primary hypothyroidism (PH) occurrence odds in residents living in the Capuava Petrochemical Complex (CPC) influence area. Methods: This area was evaluated with the combination of the AERMOD dispersion model with the Weather Research Forecast (WRF) meteorological model (2016). The concentration of atmospheric pollutants were analyzed in 2017 using meteorological data on the period from 2005 to 2009, correlating this data with the research done in 2003 to 2005. A home-based questionnaire was applied to evaluate 2004 residents, of both sexes, aged from 8 to 72 years, based on their proximity to the industrial areas; were select residents with PH. Results: Volatile organic compounds (VOCs), carbon monoxide (CO), and nitrogen dioxide (NO 2 ) concentrations presented the highest correlations between the PH odds and pollutant concentrations. Conclusion: Air pollution associated with the presence of the CPC is an important environmental factor contributing to the development of PH in the nearby population. As the first study showing this association in Brazil, research should be continued to better understand the mechanisms and to find ways to compensate for or remedy to avoid health impacts in future populations.

Suggested Citation

  • Maria Angela Zaccarelli-Marino & Rudá Alessi & Thalles Zaccarelli Balderi & Marco Antonio Garcia Martins, 2019. "Association between the Occurrence of Primary Hypothyroidism and the Exposure of the Population Near to Industrial Pollutants in São Paulo State, Brazil," IJERPH, MDPI, vol. 16(18), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:18:p:3464-:d:268145
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    References listed on IDEAS

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    1. Maria Angela Zaccarelli-Marino & Carmen Diva Saldiva André & Julio M. Singer, 2016. "Overt Primary Hypothyroidism in an Industrial Area in São Paulo, Brazil: The Impact of Public Disclosure," IJERPH, MDPI, vol. 13(11), pages 1-11, November.
    2. Nazia Uzma & B. M. Khaja Mohinuddin Salar & B. Santhosh Kumar & Nusrat Aziz & M. Anthony David & V. Devender Reddy, 2008. "Impact of Organic Solvents and Environmental Pollutants on the Physiological Function in Petrol Filling Workers," IJERPH, MDPI, vol. 5(3), pages 1-8, September.
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    Cited by:

    1. Mieczysław Szyszkowicz & Anna Lukina & Tatiana Dinu, 2022. "Urban Air Pollution and Emergency Department Visits for Neoplasms and Outcomes of Blood Forming and Metabolic Systems," IJERPH, MDPI, vol. 19(9), pages 1-13, May.

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