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Treatment with 3-Aminobenzamide Negates the Radiofrequency-Induced Adaptive Response in Two Cell Models

Author

Listed:
  • Anna Sannino

    (Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124 Naples, Italy
    These authors contributed equally to the manuscript.)

  • Olga Zeni

    (Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124 Naples, Italy
    These authors contributed equally to the manuscript.)

  • Stefania Romeo

    (Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124 Naples, Italy)

  • Maria Brigida Lioi

    (Department of Science, University of Basilicata, 85100 Potenza, Italy)

  • Maria Rosaria Scarfì

    (Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124 Naples, Italy)

Abstract

In previous investigations, we demonstrated that pre-exposure of different cell cultures to radiofrequency fields can reduce the damage induced by genotoxic agents, an effect resembling the so-called adaptive response. In this study, we pre-exposed human peripheral blood lymphocytes and Chinese hamster lung fibroblast cell line to 1950 MHz, UMTS (Universal Mobile Telecommunication System) signal, for 20 h, and then treated cultures with Mitomycin-C. After confirming the induction of an adaptive response in terms of the reduction of micronuclei formation, we observed that such a response was negated by treatments with 3-aminobenzamide. Since 3-aminobenzamide is an inhibitor of poly (ADP-ribose) polymerase enzyme, which is involved in DNA repair, these results support the possible involvement of DNA repair mechanisms in radiofrequency-induced adaptive response.

Suggested Citation

  • Anna Sannino & Olga Zeni & Stefania Romeo & Maria Brigida Lioi & Maria Rosaria Scarfì, 2019. "Treatment with 3-Aminobenzamide Negates the Radiofrequency-Induced Adaptive Response in Two Cell Models," IJERPH, MDPI, vol. 16(15), pages 1-7, August.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:15:p:2768-:d:254295
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    Cited by:

    1. Maria Rosaria Scarfì & Mats-Olof Mattsson & Myrtill Simkó & Olga Zeni, 2019. "Special Issue: “Electric, Magnetic, and Electromagnetic Fields in Biology and Medicine: From Mechanisms to Biomedical Applications”," IJERPH, MDPI, vol. 16(22), pages 1-3, November.

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