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Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8

Author

Listed:
  • Masanari Watanabe

    (Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

  • Hisashi Noma

    (Department of Data Science, Institute of Statistical Mathematics, 10-3 Midori-cho, Tachikawa, Tokyo 190-8562, Japan)

  • Jun Kurai

    (Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

  • Hiroyuki Sano

    (Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kinki University, Ohnohigashi 377-2, Osakasayama 589-0014, Japan)

  • Hiroya Kitano

    (Board of Directors, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

  • Rumiko Saito

    (Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan)

  • Yutaka Kimura

    (Department of Dermatology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan)

  • Setsuya Aiba

    (Department of Dermatology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan)

  • Mitsuo Oshimura

    (Chromosome Engineering Research Center, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

  • Eiji Shimizu

    (Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

Abstract

This study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April–May 2012, and in 384 of these children during March–May 2013. PEF’s association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 mm (PM 2.5 ) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 mg/m 3 in SPM led to PEF changes of −2.16 L/min in 2012 and −0.81 L/min in 2013, respectively. An increment of 10.7 mg/m 3 in PM 2.5 was associated with PEF changes of −2.58 L/min in 2012 and −0.55 L/min in 2013, respectively. These associations were only significant in 2012. Interleukin-8 promoter activity was significantly higher in both periods of 2012 than in 2013. There was a significant association between pulmonary function in schoolchildren and daily levels of SPM and PM 2.5 , but this association may differ depending on the PM’s ability to elicit interleukin-8 production.

Suggested Citation

  • Masanari Watanabe & Hisashi Noma & Jun Kurai & Hiroyuki Sano & Hiroya Kitano & Rumiko Saito & Yutaka Kimura & Setsuya Aiba & Mitsuo Oshimura & Eiji Shimizu, 2015. "Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8," IJERPH, MDPI, vol. 12(11), pages 1-15, November.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:11:p:14229-14243:d:58490
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    Citations

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    Cited by:

    1. Masanari Watanabe & Hisashi Noma & Jun Kurai & Degejirihu Hantan & Naoto Burioka & Sachiko Nakamoto & Hiroyuki Sano & Jumpei Taniguchi & Eiji Shimizu, 2016. "Association between Outdoor Fungal Concentrations during Winter and Pulmonary Function in Children with and without Asthma," IJERPH, MDPI, vol. 13(5), pages 1-11, April.
    2. Masanari Watanabe & Hisashi Noma & Jun Kurai & Hiroyuki Sano & Degejirihu Hantan & Masaru Ueki & Hiroya Kitano & Eiji Shimizu, 2016. "Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan," IJERPH, MDPI, vol. 13(10), pages 1-13, September.
    3. Jun Kurai & Masanari Watanabe & Hiroyuki Sano & Degejirihu Hantan & Eiji Shimizu, 2016. "The Effect of Seasonal Variations in Airborne Particulate Matter on Asthma-Related Airway Inflammation in Mice," IJERPH, MDPI, vol. 13(6), pages 1-10, June.

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