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Effect of an Intermediate-Frequency Magnetic Field of 23 kHz at 2 mT on Chemotaxis and Phagocytosis in Neutrophil-Like Differentiated Human HL-60 Cells

Author

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  • Shin Koyama

    (Laboratory of Applied Radio Engineering for Humanosphere, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan)

  • Eijiro Narita

    (Laboratory of Applied Radio Engineering for Humanosphere, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan)

  • Naoki Shinohara

    (Laboratory of Applied Radio Engineering for Humanosphere, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan)

  • Junji Miyakoshi

    (Laboratory of Applied Radio Engineering for Humanosphere, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan)

Abstract

Public concerns about potential health risks of intermediate-frequency (IF) electromagnetic fields are increasing, especially as the use of induction-heating cooktops has spread extensively in Japan and Europe. In order to investigate the properties of IF electromagnetic fields, we examined the effect of exposure to a 23-kHz IF magnetic field of 2 mT for 2, 3, or 4 h on neutrophil chemotaxis and phagocytosis using differentiated human HL-60 cells. Compared with sham exposure, exposure to the IF magnetic field had no effect on neutrophil chemotaxis or phagocytosis. Previous studies demonstrated that exposure to a 23-kHz IF magnetic field of 2 mT (about 74-times the maximum value recommended by the International Commission for Nonionizing Radiation Protection guidelines) may affect the first-line immune responses in humans. To our knowledge, this is the first study to evaluate the effects of IF magnetic fields on cellular immune responses. We found that exposure to an IF magnetic field of 2 mT has minimal if any effect on either the chemotaxis or phagocytic activity of neutrophil-like human HL-60 cells.

Suggested Citation

  • Shin Koyama & Eijiro Narita & Naoki Shinohara & Junji Miyakoshi, 2014. "Effect of an Intermediate-Frequency Magnetic Field of 23 kHz at 2 mT on Chemotaxis and Phagocytosis in Neutrophil-Like Differentiated Human HL-60 Cells," IJERPH, MDPI, vol. 11(9), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:9:p:9649-9659:d:40316
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    1. Masaru Ishii & Jackson G. Egen & Frederick Klauschen & Martin Meier-Schellersheim & Yukihiko Saeki & Jean Vacher & Richard L. Proia & Ronald N. Germain, 2009. "Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis," Nature, Nature, vol. 458(7237), pages 524-528, March.
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    Cited by:

    1. Shin Ohtani & Akira Ushiyama & Machiko Maeda & Keiji Wada & Yukihisa Suzuki & Kenji Hattori & Naoki Kunugita & Kazuyuki Ishii, 2019. "Global Analysis of Transcriptional Expression in Mice Exposed to Intermediate Frequency Magnetic Fields Utilized for Wireless Power Transfer Systems," IJERPH, MDPI, vol. 16(10), pages 1-8, May.

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