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Genetic Analysis of West Nile Virus Isolates from an Outbreak in Idaho, United States, 2006–2007

Author

Listed:
  • Andriyan Grinev

    (Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA)

  • Caren Chancey

    (Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA)

  • Germán Añez

    (Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA)

  • Christopher Ball

    (Idaho Bureau of Laboratories, Boise, ID 83712, USA)

  • Valerie Winkelman

    (Creative Testing Solutions, Tempe, AZ 85282, USA)

  • Phillip Williamson

    (Creative Testing Solutions, Tempe, AZ 85282, USA)

  • Gregory A. Foster

    (American Red Cross, Gaithersburg, MD 20877, USA)

  • Susan L. Stramer

    (American Red Cross, Gaithersburg, MD 20877, USA)

  • Maria Rios

    (Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA)

Abstract

West Nile virus (WNV) appeared in the U.S. in 1999 and has since become endemic, with yearly summer epidemics causing tens of thousands of cases of serious disease over the past 14 years. Analysis of WNV strains isolated during the 2006–2007 epidemic seasons demonstrates that a new genetic variant had emerged coincidentally with an intense outbreak in Idaho during 2006. The isolates belonging to the new variant carry a 13 nt deletion, termed ID-Δ13, located at the variable region of the 3′UTR, and are genetically related. The analysis of deletions and insertions in the 3′UTR of two major lineages of WNV revealed the presence of conserved repeats and two indel motifs in the variable region of the 3′UTR. One human and two bird isolates from the Idaho 2006–2007 outbreaks were sequenced using Illumina technology and within-host variability was analyzed. Continued monitoring of new genetic variants is important for public health as WNV continues to evolve.

Suggested Citation

  • Andriyan Grinev & Caren Chancey & Germán Añez & Christopher Ball & Valerie Winkelman & Phillip Williamson & Gregory A. Foster & Susan L. Stramer & Maria Rios, 2013. "Genetic Analysis of West Nile Virus Isolates from an Outbreak in Idaho, United States, 2006–2007," IJERPH, MDPI, vol. 10(9), pages 1-21, September.
    • Handle: RePEc:gam:jijerp:v:10:y:2013:i:9:p:4486-4506:d:28977
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    References listed on IDEAS

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    1. Yu-Hui Rogers & J. Craig Venter, 2005. "Massively parallel sequencing," Nature, Nature, vol. 437(7057), pages 326-327, September.
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