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Likelihood ratio tests for genetic linkage


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  • Lemdani, Mohamed
  • Pons, Odile
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    Mixtures of binomial distributions are used to model linkage between genes and markers. In several classical models, we study the likelihood ratio test for linkage, which are homogeneity tests in mixture models. Using ad hoc reparametrizations, we prove that the corresponding test statistics converge to the supremum of squared truncated Gaussian processes under the null hypothesis.

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    Bibliographic Info

    Article provided by Elsevier in its journal Statistics & Probability Letters.

    Volume (Year): 33 (1997)
    Issue (Month): 1 (April)
    Pages: 15-22

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    Handle: RePEc:eee:stapro:v:33:y:1997:i:1:p:15-22

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    Keywords: Binomial mixture Homogeneity Likelihood ratio test Linkage;


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    Cited by:
    1. Ning, Wei & Zhang, Sanguo & Yu, Chang, 2009. "A moment-based test for the homogeneity in mixture natural exponential family with quadratic variance functions," Statistics & Probability Letters, Elsevier, vol. 79(6), pages 828-834, March.
    2. Andrew Sweeting, 2005. "Coordination Games, Multiple Equilibria and the Timing of Radio Commercials," 2005 Meeting Papers 490, Society for Economic Dynamics.
    3. Wu, Yanhong & Xu, Yongxia, 2000. "Local likelihood ratio tests in the normal mixture model," Statistics & Probability Letters, Elsevier, vol. 50(4), pages 323-329, December.


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