IDEAS home Printed from https://ideas.repec.org/a/eee/phsmap/v537y2020ics0378437119315596.html
   My bibliography  Save this article

Congenital anomalies from a physics perspective. The key role of “manufacturing” volatility

Author

Listed:
  • Bois, Alex
  • Garcia-Roger, Eduardo M.
  • Hong, Elim
  • Hutzler, Stefan
  • Irannezhad, Ali
  • Mannioui, Abdelkrim
  • Richmond, Peter
  • Roehner, Bertrand M.
  • Tronche, Stéphane

Abstract

Genetic and environmental factors are traditionally seen as the sole causes of congenital anomalies. In this paper we introduce a third possible cause, namely random “manufacturing” discrepancies with respect to “design” values. A clear way to demonstrate the existence of this component is to “turn off” the two others and to see whether or not there is still remaining variability. Perfect clones raised under well controlled laboratory conditions fulfill the conditions for such a test. Carried out for four different species, the test reveals a variability remainder of the order of 15% in terms of coefficient of variation (i.e. ratio of standard deviation to average, subsequently denoted by CV). As an example, the CV of the volume of E. coli (Escherichia Coli) bacteria immediately after binary fission is of that order.

Suggested Citation

  • Bois, Alex & Garcia-Roger, Eduardo M. & Hong, Elim & Hutzler, Stefan & Irannezhad, Ali & Mannioui, Abdelkrim & Richmond, Peter & Roehner, Bertrand M. & Tronche, Stéphane, 2020. "Congenital anomalies from a physics perspective. The key role of “manufacturing” volatility," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 537(C).
    • Handle: RePEc:eee:phsmap:v:537:y:2020:i:c:s0378437119315596
    DOI: 10.1016/j.physa.2019.122742
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0378437119315596
    Download Restriction: Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000
    File URL: https://libkey.io/10.1016/j.physa.2019.122742?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Berrut, Sylvie & Pouillard, Violette & Richmond, Peter & Roehner, Bertrand M., 2016. "Deciphering infant mortality," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 463(C), pages 400-426.
    2. Bois, Alex & Garcia-Roger, Eduardo M. & Hong, Elim & Hutzler, Stefan & Irannezhad, Ali & Mannioui, Abdelkrim & Richmond, Peter & Roehner, Bertrand M. & Tronche, Stéphane, 2019. "Infant mortality across species. A global probe of congenital abnormalities," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 535(C).
    3. Richmond, Peter & Roehner, Bertrand M., 2016. "Predictive implications of Gompertz’s law," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 447(C), pages 446-454.
    4. Berrut, Sylvie & Richmond, Peter & Roehner, Bertrand M., 2017. "Age spectrometry of infant death rates as a probe of immunity: Identification of two peaks due to viral and bacterial diseases respectively," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 486(C), pages 915-924.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Richmond, Peter & Roehner, Bertrand M. & Irannezhad, Ali & Hutzler, Stefan, 2021. "Mortality: A physics perspective," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 566(C).
    2. Haffner, Benjamin & Lalieu, Jonathan & Richmond, Peter & Hutzler, Stefan, 2018. "Can soap films be used as models for mortality studies?," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 508(C), pages 461-470.
    3. Berrut, Sylvie & Richmond, Peter & Roehner, Bertrand M., 2017. "Age spectrometry of infant death rates as a probe of immunity: Identification of two peaks due to viral and bacterial diseases respectively," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 486(C), pages 915-924.
    4. Richmond, Peter & Roehner, Bertrand M., 2019. "A physicist’s view of the similarities and differences between tuberculosis and cancer," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 534(C).
    5. Berrut, Sylvan & Richmond, Peter & Roehner, Bertrand M., 2018. "Excess tuberculosis-mortality in young women: High accuracy exploration," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 506(C), pages 476-485.
    6. Berrut, Sylvie & Pouillard, Violette & Richmond, Peter & Roehner, Bertrand M., 2016. "Deciphering infant mortality," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 463(C), pages 400-426.
    7. Bois, Alex & Garcia-Roger, Eduardo M. & Hong, Elim & Hutzler, Stefan & Irannezhad, Ali & Mannioui, Abdelkrim & Richmond, Peter & Roehner, Bertrand M. & Tronche, Stéphane, 2019. "Infant mortality across species. A global probe of congenital abnormalities," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 535(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:phsmap:v:537:y:2020:i:c:s0378437119315596. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/physica-a-statistical-mechpplications/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.