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Asymptotic results on a class of adaptive multi-treatment designs

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  • Li-Xin, Zhang

Abstract

The play-the-winner (PW) rule is an important method in clinical trials where patients can be assigned to one of the two treatments. In the PW rule, the probability of the next patient to be assigned to a particular treatment only depends on the response of the current patient. In this paper, we consider a general kind of PW rule for multi-treatment adaptive designs, in which the probability that a treatment is assigned to the next patient depends upon both the response of the previous patient and an estimated parameter, e.g., the observed success rate. Using this kind of adaptive designs, more information of previous stages are used to update the model at each stage, and more patients may be assigned to better treatments. The strong consistency and the asymptotic normality are established for the allocation proportions.

Suggested Citation

  • Li-Xin, Zhang, 2006. "Asymptotic results on a class of adaptive multi-treatment designs," Journal of Multivariate Analysis, Elsevier, vol. 97(3), pages 586-605, March.
    • Handle: RePEc:eee:jmvana:v:97:y:2006:i:3:p:586-605
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    1. Hu, Feifang & Rosenberger, William F., 2003. "Optimality, Variability, Power: Evaluating Response-Adaptive Randomization Procedures for Treatment Comparisons," Journal of the American Statistical Association, American Statistical Association, vol. 98, pages 671-678, January.
    2. Bai, Z. D. & Hu, Feifang & Shen, Liang, 2002. "An Adaptive Design for Multi-Arm Clinical Trials," Journal of Multivariate Analysis, Elsevier, vol. 81(1), pages 1-18, April.
    3. Bai, Z. D. & Hu, Feifang, 1999. "Asymptotic theorems for urn models with nonhomogeneous generating matrices," Stochastic Processes and their Applications, Elsevier, vol. 80(1), pages 87-101, March.
    4. William F. Rosenberger & Nigel Stallard & Anastasia Ivanova & Cherice N. Harper & Michelle L. Ricks, 2001. "Optimal Adaptive Designs for Binary Response Trials," Biometrics, The International Biometric Society, vol. 57(3), pages 909-913, September.
    5. Smythe, R. T., 1996. "Central limit theorems for urn models," Stochastic Processes and their Applications, Elsevier, vol. 65(1), pages 115-137, December.
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