Stochastic models for multiple pathways of temporal natural history on co-morbidity of chronic disease
AbstractChronic diseases frequently co-occur in individuals. Susceptibility to co-morbidity, the temporal sequence and the transition rates governing the development of co-morbid diseases are often hidden or partially observable. To tackle these thorny issues we developed a series of co-morbidity stochastic models with latent variables to estimate the true proportions of susceptibility, temporal sequence, and transition rates. We begin with a bivariate co-morbidity model for two chronic diseases, then extend to a trivariate co-morbidity model for three chronic diseases, and to a generalized high-order co-morbidity model to accommodate more than three chronic diseases. To illustrate our approach we fitted the proposed model with data from a population-based health check-up for hypertension, diabetes mellitus (DM), and overweight in Matsu.
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Bibliographic InfoArticle provided by Elsevier in its journal Computational Statistics & Data Analysis.
Volume (Year): 57 (2013)
Issue (Month): 1 ()
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Web page: http://www.elsevier.com/locate/csda
Chronic disease; Co-morbidity; Latent variable; Markov process;
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