Advanced Search
MyIDEAS: Login

Testing ratio of marginal probabilities in clustered matched-pair binary data


Author Info

  • Yang, Zhao
  • Sun, Xuezheng
  • Hardin, James W.
Registered author(s):


    In diagnostic methods evaluation, analysts commonly focus on the relative size of the treatment difference (ratio of marginal probabilities) between a new and an existing procedures. To assess non-inferiority (a new procedure is, to a pre-specified amount, no worse than an existing procedure) via a ratio of marginal probabilities between two procedures using clustered matched-pair binary data, four ICC-adjusted test statistics are investigated. The calculation of corresponding confidence intervals is also proposed. None of the tests considered require structural within-cluster correlation or distributional assumptions. Results of an extensive Monte Carlo simulation study illustrate that the new approaches effectively maintain the nominal Type I error even for small numbers of clusters. Thus, to design and evaluate non-inferiority via a ratio of marginal probabilities, researchers are suggested to utilize designs that have small cluster-size variability (e.g., nk≤5). Finally, to illustrate the practical application of the tests and recommendations, a real clustered matched-pair collection of data is used to illustrate testing non-inferiority.

    Download Info

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
    File URL:
    Download Restriction: Full text for ScienceDirect subscribers only.

    As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.

    Bibliographic Info

    Article provided by Elsevier in its journal Computational Statistics & Data Analysis.

    Volume (Year): 56 (2012)
    Issue (Month): 6 ()
    Pages: 1829-1836

    as in new window
    Handle: RePEc:eee:csdana:v:56:y:2012:i:6:p:1829-1836

    Contact details of provider:
    Web page:

    Related research

    Keywords: Clustered matched-pair binary data; Diagnostic testing; Ratio; Marginal probabilities; Non-inferiority;


    No references listed on IDEAS
    You can help add them by filling out this form.



    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.


    Access and download statistics


    When requesting a correction, please mention this item's handle: RePEc:eee:csdana:v:56:y:2012:i:6:p:1829-1836. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Zhang, Lei).

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.