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Dietary Lactobacillus plantarum alleviated Salmonella Typhimurium infection and suppressed Jak/Stat pathway in rabbits

Author

Listed:
  • F Wen

    (Department of Animal Production, Henan University of Science and Technology, Luoyang, P.R. China)

  • X Liu

    (Department of Animal Production, Henan University of Science and Technology, Luoyang, P.R. China)

  • K Ding

    (Department of Animal Production, Henan University of Science and Technology, Luoyang, P.R. China)

  • F Zhang

    (Luoyang Xintai Agro-pastoral Technology Co., Ltd., Luoyang, P.R. China)

  • J Wang

    (Department of Animal Production, Henan University of Science and Technology, Luoyang, P.R. China)

Abstract

This study aimed to investigate the effect of a Lactobacillus plantarum DPP8 supplementation on the growth performance, pathogenic invasion, inflammation and pathogen resistance signal pathway in rabbits infected with Salmonella Typhimurium (S. Typhimurium). The treatments included a negative control, a positive control with an S. Typhimurium infection and a positive control plus DPP8 at 106, 108 or 1010 cfu/kg of diet using 300 weaned rabbits. The results showed that supplementing with DPP8 improved (P < 0.05) the feed intake, body weight gain and feed efficiency compared to the positive control. Also, DPP8 decreased (P < 0.05) the S. Typhimurium colonisation and translocation, serum IL-1β, IL-6 and TNF-α, and intestinal mucosa mRNA expressions of the inflammatory mediators Janus kinase (Jak) 2, the signal transducer and activator of transcription (Stat) 1 and 3 at 7 and 14 d post administration. The dose analysis of DPP8 showed linear increases (P ≤ 0.007) in the feed intake and body weight gain, but linear decreases (P ≤ 0.022) in the S. Typhimurium loads, IL-1β, IL-6 and Jak2. It is concluded that Lactobacillus plantarum DPP8 can be used as a supportive probiotic against an S. Typhimurium infection and it possibly plays a direct or indirect role in the downregulation of the Jak/Stat pathway in rabbits.

Suggested Citation

  • F Wen & X Liu & K Ding & F Zhang & J Wang, 2022. "Dietary Lactobacillus plantarum alleviated Salmonella Typhimurium infection and suppressed Jak/Stat pathway in rabbits," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(10), pages 519-526.
    • Handle: RePEc:caa:jnlvet:v:67:y:2022:i:10:id:34-2021-vetmed
    DOI: 10.17221/34/2021-VETMED
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    Keywords

    growth performance; inflammatory cytokines;

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