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Aggressive behaviour of Hodgkin's-like lymphoma in a domestic ferret

Author

Listed:
  • HS Kim

    (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea)

  • HJ Kim

    (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
    Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California, Los Angeles, CA, United States
    Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA, United States)

  • HJ Hwang

    (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea)

  • S Oh

    (OSH Veterinary Clinic, Seoul, Republic of Korea)

  • SH Do

    (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea)

Abstract

A 3-year-old castrated male ferret was suspected to have lymphoma based on a markedly enlarged mesenteric lymph node. Hodgkin's-like lymphoma (HLL) was suspected because numerous Reed-Sternberg-like cells were observed in the fine-needle aspiration biopsy of the mesenteric lymph node. In the post-mortem histopathology, neoplastic cells were invasively proliferated not only in the mesenteric lymph nodes, but also in the liver and spleen. Immunohistochemically, most neoplastic cells were positive for vimentin and BLA-36, weakly positive for CD20, and negative for Pax5, CD79a, CD3, CD45, and Iba-1, demonstrating similarity to human Hodgkin's lymphoma (HL). In addition, a prominent programmed cell death protein 1 (PD-1) expression was observed at the sites showing malignant tumour proliferation. HLL in non-human beings can be morphologically and immunophenotypically similar to human HL, but the prognosis and clinical outcome may differ. This is the first study analysing the PD-1 expression in a ferret, suggesting that PD-1 can be a novel diagnostic and prognostic factor in a similar manner to humans.

Suggested Citation

  • HS Kim & HJ Kim & HJ Hwang & S Oh & SH Do, 2021. "Aggressive behaviour of Hodgkin's-like lymphoma in a domestic ferret," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 66(5), pages 225-232.
    • Handle: RePEc:caa:jnlvet:v:66:y:2021:i:5:id:115-2020-vetmed
    DOI: 10.17221/115/2020-VETMED
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