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Decrease in C-reactive protein levels in rabbits after vaccination with a live attenuated myxoma virus vaccine

Author

Listed:
  • L. Ondruska

    (National Agricultural and Food Centre, Research Institute for Animal Production Nitra, Luzianky, Slovak Republic)

  • V. Parkanyi

    (National Agricultural and Food Centre, Research Institute for Animal Production Nitra, Luzianky, Slovak Republic)

  • J. Vasicek

    (National Agricultural and Food Centre, Research Institute for Animal Production Nitra, Luzianky, Slovak Republic)

  • R. Jurcik

    (National Agricultural and Food Centre, Research Institute for Animal Production Nitra, Luzianky, Slovak Republic)

  • E. Hanusova

    (National Agricultural and Food Centre, Research Institute for Animal Production Nitra, Luzianky, Slovak Republic)

  • D. Vasicek

    (National Agricultural and Food Centre, Research Institute for Animal Production Nitra, Luzianky, Slovak Republic)

  • A. Balazi

    (National Agricultural and Food Centre, Research Institute for Animal Production Nitra, Luzianky, Slovak Republic)

  • F. Vizzarri

    (University of Molise, Campobasso, Italy)

Abstract

The aim of this study was to evaluate the acute phase reaction and immune response of rabbits triggered by vaccination with a live attenuated myxoma virus (MXT) vaccine. Thirteen adult and 11 juvenile New Zealand white rabbit-based crossbreed rabbits, were used. Samples of rabbit peripheral blood were collected from vena auricularis centralis into heparinised tubes before vaccination and 48 h after vaccination. All animals were vaccinated by subcutaneous injection (0.5 ml) with a MXT vaccine. The blood plasma C-reactive protein level was measured by an ELISA kit using a double-antibody sandwich. For phenotyping of lymphocytes the fresh cells were stained with the following anti-rabbit monoclonal antibodies: anti-IgM, anti-CD4, anti-CD8 and anti-pan T2. Our results show that the use of attenuated myxoma virus vaccine significantly decreases the level of C-reactive protein in blood plasma of adult rabbits by 38.14% (P < 0.05) and of juvenile rabbits by 37.63% (P < 0.001), within 48 h. The rabbit C-reactive protein after MXT vaccination is a negative acute phase protein. In the group of adult rabbits the immune response to MXT vaccination was accompanied by a non-significant decrease in CD4+, pT2+, IgM+ subsets. On the other hand the values of CD8+, CD4+CD8+ and CD4+/CD8+ were non-significantly higher after MXT vaccination.

Suggested Citation

  • L. Ondruska & V. Parkanyi & J. Vasicek & R. Jurcik & E. Hanusova & D. Vasicek & A. Balazi & F. Vizzarri, 2016. "Decrease in C-reactive protein levels in rabbits after vaccination with a live attenuated myxoma virus vaccine," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 61(10), pages 571-576.
    • Handle: RePEc:caa:jnlvet:v:61:y:2016:i:10:id:159-2015-vetmed
    DOI: 10.17221/159/2015-VETMED
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    References listed on IDEAS

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    1. C. Tothova & O. Nagy & G. Kovac, 2014. "Acute phase proteins and their use in the diagnosis of diseases in ruminants: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 59(4), pages 163-180.
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