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Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies

Author

Listed:
  • A.C. Spichiger

    (Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,)

  • K. Allenspach

    (Department of Clinical Veterinary Medicine, University of Bern, Bern, Switzerland)

  • Y. Zbinden

    (Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,)

  • M.G. Doherr

    (Department of Clinical Veterinary Medicine, University of Bern, Bern, Switzerland)

  • S. Hiss

    (Institute of Animal Science, Physiology and Hygiene, University of Bonn, Bonn, Germany)

  • J.W. Blum

    (Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,)

  • S.N. Sauter

    (Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,)

Abstract

Plasma concentrations of insulin-like growth factor (IGF)-1 were examined in dogs suffering from food-responsive diarrhea (group FRD) or inflammatory bowel disease (group IBD) before and after treatment and compared with IGF-1 values in healthy dogs (group C). Blood of 76 dogs was sampled (FRDbefore treatment, n = 23; IBD before treatment, n = 11; C, n = 42) and after treatment (FRD, n = 15; IBD, n= 8) with a hypoallergenic diet combined with (group IBD) or without prednisolone (group FRD). A clinical score (Canine IBD Activity Index = CIBDAI) was applied to judge the health status in all dogs. Plasma concentration of IGF-1, of total protein, albumin, glucose, urea, non-esterified fatty acids (NEFA), and of the acute phase protein haptoglobin was measured in all dogs. The CIBDAI scores decreased during the treatment period in FRD and IBD (P < 0.05). IGF-1 concentrations were positively correlated with body weight (BW) (rsp = 0.65, P < 0.001) and values of IGF-1 were therefore normalized with BW. IGF-1/BW ratios were lower in FRD and IBD before treatment than in C (P < 0.01). IGF-1/BW ratios increased in FRD (P < 0.05) dogs during treatment. Plasma glucose concentration was lower in FRD dogs before treatment than in C (P < 0.05), and NEFA concentrations were higher in FRDdogs before and after treatment than in C (P < 0.001). Haptoglobin concentrations were higher in IBD dogs before and after treatment than in all other groups (P < 0.05). In conclusion, chronic enteropathies reduce the plasma IGF-1 status in dogs. The increase of the IGF-1/BW ratio after treatment suggests that plasma IGF-1 concentration may help to judge the outcome of chronic enteropathies in dogs.

Suggested Citation

  • A.C. Spichiger & K. Allenspach & Y. Zbinden & M.G. Doherr & S. Hiss & J.W. Blum & S.N. Sauter, 2006. "Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 51(1), pages 35-43.
    • Handle: RePEc:caa:jnlvet:v:51:y:2006:i:1:id:5515-vetmed
    DOI: 10.17221/5515-VETMED
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    Cited by:

    1. S.N. Sauter & K. Allenspach & J.W. Blum, 2007. "Cytokine mRNA abundance in intestinal biopsies from dogs with chronic diarrhea," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 52(8), pages 353-364.

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