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Expression analysis of BMPR1B, BMP15, and GDF9 in prolific and non-prolific sheep breeds during the follicular phase

Author

Listed:
  • Ji-Shun Tang

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P.R. China
    Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei, P.R. China)

  • Wen-Ping Hu

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P.R. China)

  • Ran Di

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P.R. China)

  • Xiang-Yu Wang

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P.R. China)

  • Xiao-Sheng Zhang

    (Tianjin Institute of Animal Sciences, Tianjin, P.R. China)

  • Jin-Long Zhang

    (Tianjin Institute of Animal Sciences, Tianjin, P.R. China)

  • Qiu-Yue Liu

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P.R. China)

  • Ming-Xing Chu

    (Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, P.R. China)

Abstract

To elucidate how expression characteristics of BMPR1B, BMP15, and GDF9 are associated with sheep reproduction, tissue-specific mRNA expression of these genes in Small Tail Han (STH) ewes (a polytocous breed) and Sunite (SNT) ewes (a monotocous breed) in the follicular phase were investigated using transcription profiling and quantitative real-time PCR (qPCR). Expression levels of the three genes were all highest in ovaries of the two sheep breeds, and BMPR1B and GDF9 expression in the ovarian tissue was significantly higher in STH sheep compared with SNT sheep (P < 0.01), whereas BMP15 expression in pituitary, ovarian, oviduct, and uterine tissues was significantly lower in STH sheep compared with SNT sheep (P < 0.01). This study revealed that BMPR1B, BMP15, and GDF9 may play important roles in the hypothalamic-pituitary-gonadal axis, especially in the ovary, which may affect sheep prolificacy. BMPR1B and GDF9 expression might increase litter size, whereas BMP15 expression may decrease litter size. These results provide preliminary information regarding molecular regulatory mechanisms underlying sheep prolificacy.

Suggested Citation

  • Ji-Shun Tang & Wen-Ping Hu & Ran Di & Xiang-Yu Wang & Xiao-Sheng Zhang & Jin-Long Zhang & Qiu-Yue Liu & Ming-Xing Chu, 2019. "Expression analysis of BMPR1B, BMP15, and GDF9 in prolific and non-prolific sheep breeds during the follicular phase," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 64(11), pages 439-447.
    • Handle: RePEc:caa:jnlcjs:v:64:y:2019:i:11:id:101-2018-cjas
    DOI: 10.17221/101/2018-CJAS
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    References listed on IDEAS

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    1. Z.Y. Pan & R. Di & Q.Q. Tang & H.H. Jin & M.X. Chu & D.W. Huang & J.N. He & Q.Y. Liu & W.P. Hu & X.Y. Wang & Y.X. Yao & L. Liu & C.L. Song, 2015. "Tissue-specific mRNA expression profiles of GDF9, BMP15, and BMPR1B genes in prolific and non-prolific goat breeds," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 60(10), pages 452-458.
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