IDEAS home Printed from https://ideas.repec.org/a/caa/jnlcjs/v63y2018i2id29-2017-cjas.html
   My bibliography  Save this article

Tissue specific splicing of pre-mRNA porcine mitochondrial transcription factor A

Author

Listed:
  • Andrej Renčelj

    (Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domžale, Slovenia)

  • Martin Škrlep

    (Animal Production Department, Agricultural Institute of Slovenia, Ljubljana, Slovenia)

  • Meta Čandek-Potokar

    (Animal Production Department, Agricultural Institute of Slovenia, Ljubljana, Slovenia)

  • Peter Dovč

    (Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domžale, Slovenia)

Abstract

Mitochondrial transcription factor A plays, due to its role in replication and transcription of the mitochondrial DNA, an important role in mitochondrial biogenesis and regulation of its activity. In different mammalian species, mitochondrial transcription factor A is present in two different splicing forms. The aim of the study was to verify the presence of both splicing forms and to estimate their ratio in different tissues. The expression levels of both splicing forms in two skeletal muscles (m. semispinalis capitis and m. semimembranosus), heart muscle, brain, spleen, and liver in commercial hybrids and in the autochthonous Krsko polje pig breed are reported. In all analyzed tissues the expression of the long form of the mitochondrial transcription factor A was about one order of magnitude higher compared to the short form, lacking almost the entire exon 4 region. Taking into account the expression ratio of both splicing forms and biological function of the mitochondrial transcription factor A, the possible explanation for the persistence of both forms in different mammalian species is provided.

Suggested Citation

  • Andrej Renčelj & Martin Škrlep & Meta Čandek-Potokar & Peter Dovč, 2018. "Tissue specific splicing of pre-mRNA porcine mitochondrial transcription factor A," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 63(2), pages 43-50.
    • Handle: RePEc:caa:jnlcjs:v:63:y:2018:i:2:id:29-2017-cjas
    DOI: 10.17221/29/2017-CJAS
    as

    Download full text from publisher

    File URL: http://cjas.agriculturejournals.cz/doi/10.17221/29/2017-CJAS.html
    Download Restriction: free of charge
    File URL: http://cjas.agriculturejournals.cz/doi/10.17221/29/2017-CJAS.pdf
    Download Restriction: free of charge
    File URL: https://libkey.io/10.17221/29/2017-CJAS?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlcjs:v:63:y:2018:i:2:id:29-2017-cjas. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.