IDEAS home Printed from https://ideas.repec.org/a/caa/jnlcjs/v60y2015i9id8458-cjas.html
   My bibliography  Save this article

Opioid-induced hypophagia is mediated by 5-HT2c receptors in neonatal layer-type chicken

Author

Listed:
  • M. Shojaei

    (Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran)

  • M. Zendehdel

    (Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran)

  • V. Babapour

    (Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran)

  • S. Charkhkar

    (Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran)

  • S. Hassanpour

    (Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran)

Abstract

Opioidergic and serotonergic (5-HTergic) systems have crucial role in central regulation of food intake. This study was designed to investigate the role of the opioidergic system and the interaction with the 5-HTergic system in opioid-induced feeding behaviour in 3-h food-deprived (FD3) neonatal layer-type chicks. In total 432 chickens were allocated into 9 experiments, each per 4 treatment groups. In Experiment 1, birds were intracerebroventricularly (ICV) injected with D-Ala2-NMe-Phe4-Glyol5-enkephalin (DAMGO), µ-opioid receptor agonist (125, 250, and 500 pmol). In Experiment 2, chickens were ICV treated with D-Pen2, D-Pen5enkephalin (D-Pen2,5enkephalin, DPDPE), δ-opioid receptor agonist (20, 40, and 80 pmol). In Experiment 3, the effect of ICV injection of U-50488H, κ-opioid receptor agonist (10, 20, and 30 nmol) was investigated in chicks. In Experiment 4, chickens were injected with para-chlorophenylalanine (PCPA), cerebral serotonin depletive (1.5 µg) + DAMGO (125 pmol). In Experiment 5, birds were treated with PCPA (1.5 µg) + DPDPE (40 pmol). In Experiment 6, birds received 1.5 µg PCPA + U-50488H (30 nmol). In Experiments 7-9, birds were injected like in Experiments 4-6, but with SB242084, 5-HT2c receptor antagonist (1.5 µg) instead of the PCPA injection. Cumulative food intake was recorded until 3 h post injection. According to the results, the ICV injection of DAMGO significantly decreased whereas that of DPDPE + U-50488H increased food intake (P ≤ 0.05). Co-administration of PCPA + DAMGO significantly decreased hypophagia induced by DAMGO (P ≤ 0.05). PCPA had no effect on DPDPE + U-50488H-induced hyperphagia (P ≥ 0.05). SB242084 significantly attenuated the hypophagic effect of DAMGO (P ≤ 0.05), while SB242084 had no modulatory effect on the food intake induced by DPDPE + U-50488H (P ≥ 0.05). These results suggest that there is an interaction between the opioidergic and 5-HTergic systems mediating the hypophagic effect of µ-opioid receptors via the 5-HT2c receptor in neonatal layer-type chicks.

Suggested Citation

  • M. Shojaei & M. Zendehdel & V. Babapour & S. Charkhkar & S. Hassanpour, 2015. "Opioid-induced hypophagia is mediated by 5-HT2c receptors in neonatal layer-type chicken," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 60(9), pages 400-410.
    • Handle: RePEc:caa:jnlcjs:v:60:y:2015:i:9:id:8458-cjas
    DOI: 10.17221/8458-CJAS
    as

    Download full text from publisher

    File URL: http://cjas.agriculturejournals.cz/doi/10.17221/8458-CJAS.html
    Download Restriction: free of charge
    File URL: http://cjas.agriculturejournals.cz/doi/10.17221/8458-CJAS.pdf
    Download Restriction: free of charge
    File URL: https://libkey.io/10.17221/8458-CJAS?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shoresh Arva & Morteza Zendehdel & Yahya Ebrahim Nezhad & Jamshid Ghiasi Ghalehkandi & Shahin Hassanpour & Habib Aghdam Shahryar, 2017. "Effect of opioid receptors agonists on feeding behaviour using different diets in ad libitum fed neonatal chicken," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 62(3), pages 98-109.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:caa:jnlcjs:v:60:y:2015:i:9:id:8458-cjas. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Ivo Andrle (email available below). General contact details of provider: https://www.cazv.cz/en/home/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.