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Sea buckthorn (Hippophae rhamnoides L.) oil exhibits antifungal activity against Aspergillus flavus via disrupting mitochondrial function

Author

Listed:
  • Yanhua Xin

    (Department of Bioengineering, Xinzhou Teachers University, Xinzhou, China
    Ones Sun Health Industry Limited Company, Guangdong, China)

  • Jie Yang

    (Department of Bioengineering, Xinzhou Teachers University, Xinzhou, China)

  • Sanhu Zhao

    (Department of Bioengineering, Xinzhou Teachers University, Xinzhou, China)

  • Kewen Chen

    (Department of Bioengineering, Xinzhou Teachers University, Xinzhou, China)

  • Yaqin Zhao

    (Department of Bioengineering, Xinzhou Teachers University, Xinzhou, China)

  • Tiedan Zhang

    (Ones Sun Health Industry Limited Company, Guangdong, China)

  • Jianhua Zhang

    (Department of Bioengineering, Xinzhou Teachers University, Xinzhou, China)

Abstract

The present study sought to examine how sea buckthorn (SBT) oil impacts mitochondrial and overall functionality in Aspergillus flavus. In order to assess the effect of SBT oil, it was used to treat mycelia across a range of concentrations, after which mitochondrial structures were imaged via transmission electron microscopy (TEM). In order to explore the functional impact of this treatment, we additionally examined reactive oxygen species (ROS) production, malondialdehyde (MDA) levels, enzyme activity, and shifts in mitochondrial membrane potential (ΔΨm) following treatment. We found that SBT oil induced mitochondrial damage in A. flavus in a dose-dependent manner, resulting in altered succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase) activity, reduced ΔΨm levels, and markedly elevated MDA and ROS levels. Together, these findings suggest that SBT oil can mediate antifungal activity against A. flavus through a mechanism associated with its ability to disrupt the tricarboxylic acid (TCA) cycle and mitochondrial potential, leading to MDA and ROS accumulation.

Suggested Citation

  • Yanhua Xin & Jie Yang & Sanhu Zhao & Kewen Chen & Yaqin Zhao & Tiedan Zhang & Jianhua Zhang, 2022. "Sea buckthorn (Hippophae rhamnoides L.) oil exhibits antifungal activity against Aspergillus flavus via disrupting mitochondrial function," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 40(3), pages 179-186.
  • Handle: RePEc:caa:jnlcjf:v:40:y:2022:i:3:id:234-2020-cjfs
    DOI: 10.17221/234/2020-CJFS
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