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Antimutagenic effect of genistein

Author

Listed:
  • Zdeňka Polívková

    (Division of General Biology and Genetics, Center of Biomedical Sciences and)

  • Martina Langová

    (Division of General Biology and Genetics, Center of Biomedical Sciences and)

  • Petr Šmerák

    (Division of General Biology and Genetics, Center of Biomedical Sciences and)

  • Jiřina Bártová

    (Division of General Hygiene, Center of Preventive Medicine, 3 rd Faculty of Medicine, Charles University, Prague, Czech Republic)

  • Ivo Bárta

    (Division of General Biology and Genetics, Center of Biomedical Sciences and)

Abstract

A great variety of health benefits including the protection against breast and prostate cancers has been attributed to the soya consumption, because of the presence of soy beans isoflavones, genistein, and others. We investigated the antigenotoxic effect of genistein on the genotoxicity of three mutagens and carcinogens - aflatoxine B1 (AFB1), 2-amino-3-methylimidazo [4,5-f]quinoline (IQ), and N-nitroso-N-methylurea (MNU), using the Ames bacterial mutagenicity test and the micronucleus test. In the Ames test on Salmonella typhimurium, a significant antimutagenic effect was determined against the indirect mutagen AFB1 in two strains, TA98 and TA100. However, the effect on the IQ indirect mutagenicity was more pronounced in the test with TA98 than with TA100. The mutagenicity of the direct mutagen MNU was suppressed by genistein only at its highest concentration used (300 µg/plate). The protective effect of genistein against all three mutagens was proved in the micronucleus test as the treatment of mice with the combinations of genistein and mutagens resulted in a significant reduction of the number of micronuclei in comparison with the number of micronuclei induced by the individual mutagens alone.

Suggested Citation

  • Zdeňka Polívková & Martina Langová & Petr Šmerák & Jiřina Bártová & Ivo Bárta, 2006. "Antimutagenic effect of genistein," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 24(3), pages 119-126.
    • Handle: RePEc:caa:jnlcjf:v:24:y:2006:i:3:id:3306-cjfs
    DOI: 10.17221/3306-CJFS
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    Keywords

    chemoprevention; aflatoxin B1; 2-amino-3-methylimidazo [4; 5-f]quinoline; N-nitroso-N-methylurea; Ames test; micronucleus test;
    All these keywords.

    JEL classification:

    • B1 - Schools of Economic Thought and Methodology - - History of Economic Thought through 1925

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