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Antimutagenic effect of resveratrol

Author

Listed:
  • Martina Langová

    (Department of General Biology and Genetics, Center of Biomedical Science and)

  • Zdeňka Polívková

    (Department of General Biology and Genetics, Center of Biomedical Science and)

  • Petr Šmerák

    (Department of General Biology and Genetics, Center of Biomedical Science and)

  • Jiřina Bártová

    (Department of General Hygiene, Center of Preventive Medicine, 3 rd Faculty of Medicine, Charles University, Prague, Czech Republic)

  • Ivo Bárta

    (Department of General Biology and Genetics, Center of Biomedical Science and)

Abstract

Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutagenic activity of three mutagens, i.e. aflatoxin B1 (AFB1), 2-amino-3-methylimidazo[4,5-f]qui-noline (IQ) and N-nitroso-N-methylurea (MNU) using the Ames and the micronucleus tests. In the Ames test, we proved a significant antimutagenic activity only against the indirect mutagens AFB1 and IQ, not against the direct mutagen MNU. A significant decrease of mutagenicity of all three mutagens was detected by the micronucleus test.

Suggested Citation

  • Martina Langová & Zdeňka Polívková & Petr Šmerák & Jiřina Bártová & Ivo Bárta, 2005. "Antimutagenic effect of resveratrol," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 23(5), pages 202-208.
    • Handle: RePEc:caa:jnlcjf:v:23:y:2005:i:5:id:3392-cjfs
    DOI: 10.17221/3392-CJFS
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    References listed on IDEAS

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    1. P. Šmerák & H. Šestáková & Z. Polívková & I. Bárta & B. Turek & J. Bártová & M. Langová & M. Anděl, 2002. "Antimutagenic effect of ellagic acid and its effect on the immune response in mice," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 20(5), pages 181-191.
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      Keywords

      resveratrol; aflatoxin B1; 2-amino-3-methylimidazo[4; 5-f]quinoline; N-nitroso-N-methylurea;
      All these keywords.

      JEL classification:

      • B1 - Schools of Economic Thought and Methodology - - History of Economic Thought through 1925

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