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Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B1

Author

Listed:
  • P. Šmerák

    (3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic)

  • I. Bárta

    (3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic)

  • Z. Polívková

    (3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic)

  • J. Bártová

    (3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic)

  • M. Sedmíková

    (3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic)

Abstract

The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B1,which is known to be a strong mutagen. Mutagenic activity was investigated using the Ames test in a prokaryote model at low doses (close to 0.1 LD50). Whereas the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB1, or as a combination of all three mycotoxins, they showed a mutagenic effect significantly greater than AFB1 alone in the Ames test (in strain TA98 at all concentrations) as well as in the micronucleus test (combination of T-2 toxin with AFB1).

Suggested Citation

  • P. Šmerák & I. Bárta & Z. Polívková & J. Bártová & M. Sedmíková, 2001. "Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B1," Czech Journal of Food Sciences, Czech Academy of Agricultural Sciences, vol. 19(3), pages 90-96.
    • Handle: RePEc:caa:jnlcjf:v:19:y:2001:i:3:id:6583-cjfs
    DOI: 10.17221/6583-CJFS
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    More about this item

    Keywords

    mutagenic activity; Ames test; micronucleus test; mycotoxins; aflatoxin B1; T-2 toxin; vomitoxin;
    All these keywords.

    JEL classification:

    • B1 - Schools of Economic Thought and Methodology - - History of Economic Thought through 1925

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