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Case-Control Breast Cancer Study of MALDI-TOF Proteomic Mass Spectrometry Data on Serum Samples

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  • van der Werff Martijn P. J.

    (Leiden University Medical Center)

  • Mertens Bart

    (Leiden University Medical Center)

  • de Noo Mirre E

    (Leiden University Medical Center)

  • Bladergroen Marco R

    (Leiden University Medical Center)

  • Dalebout Hans C

    (Leiden University Medical Center)

  • Tollenaar Rob A. E. M.

    (Leiden University Medical Center)

  • Deelder Andre M

    (Leiden University Medical Center)

Abstract

We introduce mass spectrometry proteomic research for diagnosis from a clinical perspective, with special reference to early-stage breast cancer detection. The nature of SELDI and MALDI mass spectrometric measurement is discussed. We explain how the mass spectral data arising from this technology may be viewed as a new data type. Some of the properties of the data are discussed and we show how such spectra may be interpreted. Sample preprocessing for mass spectrometry is introduced and a literature review of research in clinical proteomics is presented. Finally, we provide a detailed description of the study design on the breast cancer case-control study which is investigated in this special issue.

Suggested Citation

  • van der Werff Martijn P. J. & Mertens Bart & de Noo Mirre E & Bladergroen Marco R & Dalebout Hans C & Tollenaar Rob A. E. M. & Deelder Andre M, 2008. "Case-Control Breast Cancer Study of MALDI-TOF Proteomic Mass Spectrometry Data on Serum Samples," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 7(2), pages 1-14, January.
    • Handle: RePEc:bpj:sagmbi:v:7:y:2008:i:2:n:2
    DOI: 10.2202/1544-6115.1352
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