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The Combined Effect of Two Factors on Disease in a Case‐Control Study

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  • M. J. Gardner
  • A. G. Munford

Abstract

Case‐control studies are widely used in medical investigations as they can be designed to give rapid tests of aetiological hypotheses of chronic diseases. The joint action of more than one possible causative agent is becoming of increasing interest. A method for testing whether the combined presence of two dichotomous variables has an additive or multiplicative effect is described. The results are then applied to the particular data which gave rise to this investigation, and some extensions of the method discussed.

Suggested Citation

  • M. J. Gardner & A. G. Munford, 1980. "The Combined Effect of Two Factors on Disease in a Case‐Control Study," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 29(3), pages 276-281, November.
    • Handle: RePEc:bla:jorssc:v:29:y:1980:i:3:p:276-281
    DOI: 10.2307/2346902
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