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Adaptive design in surveys and clinical trials: similarities, differences and opportunities for cross‐fertilization

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  • Michael Rosenblum
  • Peter Miller
  • Benjamin Reist
  • Elizabeth A. Stuart
  • Michael Thieme
  • Thomas A. Louis

Abstract

Adaptive designs involve preplanned rules for modifying an on‐going study based on accruing data. We compare the goals and methods of adaptation for trials and surveys, identify similarities and differences, and make recommendations for what types of adaptive approaches from one domain have high potential to be useful in the other. For example, clinical trials could benefit from recently developed survey methods for monitoring which groups have low response rates and intervening to fix this. Clinical trials may also benefit from more formal identification of the target population, and from using paradata (contextual information collected before or during the collection of actual outcomes) to predict participant compliance and retention and then to intervene to improve these. Surveys could benefit from stopping rules based on information monitoring, applying techniques from sequential multiple‐assignment randomized trial designs to improve response rates, prespecifying a formal adaptation protocol and including a data monitoring committee. We conclude with a discussion of the additional information, infrastructure and statistical analysis methods that are needed when conducting adaptive designs, as well as benefits and risks of adaptation.

Suggested Citation

  • Michael Rosenblum & Peter Miller & Benjamin Reist & Elizabeth A. Stuart & Michael Thieme & Thomas A. Louis, 2019. "Adaptive design in surveys and clinical trials: similarities, differences and opportunities for cross‐fertilization," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 182(3), pages 963-982, June.
  • Handle: RePEc:bla:jorssa:v:182:y:2019:i:3:p:963-982
    DOI: 10.1111/rssa.12438
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    Cited by:

    1. Stephanie Coffey, PhD. & Jaya Damineni & John Eltinge, PhD. & Anup Mathur, PhD. & Kayla Varela & Allison Zotti, 2023. "Some Open Questions on Multiple-Source Extensions of Adaptive-Survey Design Concepts and Methods," Working Papers 23-03, Center for Economic Studies, U.S. Census Bureau.

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