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Ex vivo Determination of Prostate Specific Antigen (PSA) Using Green Synthesized Magnetic Iron-Oxide Nanoparticles (IONPS)

Author

Listed:
  • Muhd BK

    (Department of Biotechnology Federal University Dutse PMB 7156, Nigeria)

  • Umar AA

    (Department of Biotechnology Federal University Dutse PMB 7156, Nigeria)

  • Muhammad Y.

    (Department of Chemical pathology, Rasheed Shekoni Specialist Hospital Dutse, Nigeria)

  • Kani YA.

    (College of Medicine and Health Sciences, Federal University Dutse, Nigeria)

  • Iliya S.

    (Department of Biological Sciences, School of Pure and Applied Sciences, Mount Kenya University Thika, Kenya)

  • Wali U.

    (Department of Chemical Pathology Faculty of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, Nigeria)

  • Tahiru A.

    (Department of Chemical pathology, Rasheed Shekoni Specialist Hospital Dutse, Nigeria)

  • Abubakar UF

    (Public Health and Diagnostic Institute, Yusuf Maitama Sule University Kano, Nigeria)

  • Shehu Z.

    (Department of Chemical Pathology Faculty of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, Nigeria)

  • Ahmed AY.

    (Department of Science Laboratory Technology, Jigawa State Polytechnic, Nigeria)

  • Zainab I

    (Department of Hematology and Blood Group Serology, Rasheed Shekoni Specialist Hospital Dutse, Nigeria)

Abstract

The discovery and introduction of prostate-specific antigen (PSA) testing into clinical medicine enable the diagnosis, treatment and monitoring of prostatic carcinoma, and further revolutionized the management of patients with prostate cancer. Among the current developments in molecular detection of PSA is ELISA. The current research aimed at synthesizing the magnetic Iron-oxide nanoparticles for detection (assay) of prostate specific antigen and comparing the results obtained with that of the ELISA technique. It provides new advancements in molecular detections of PSA using magnetic iron-oxide nanoparticles. The magnetites were green synthesized using blackberry leaves extract, FeCl2.4H2O and FeCl3.6H2O. Serum samples (n=30) were treated and subjected to both ELISA and magnetic iron-oxide nanoparticles immunoassay techniques. Descriptive statistical analysis (α=.05) of T-test, chi-square and ANOVA using SPSS software package, reveals (p

Suggested Citation

  • Muhd BK & Umar AA & Muhammad Y. & Kani YA. & Iliya S. & Wali U. & Tahiru A. & Abubakar UF & Shehu Z. & Ahmed AY. & Zainab I, 2020. "Ex vivo Determination of Prostate Specific Antigen (PSA) Using Green Synthesized Magnetic Iron-Oxide Nanoparticles (IONPS)," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 7(4), pages 296-302, April.
    • Handle: RePEc:bjc:journl:v:7:y:2020:i:4:p:296-302
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