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Antimicrobial Evaluation of New Synthesized Aza Heterocycles

Author

Listed:
  • Manahil B. Elamin*

    (Department of chemistry, Faculty of Science, Majmaah University 11952, Saudi Arabia)

  • Shazalia M. Ali

    (Department of chemistry, Faculty of Science, Majmaah University 11952, Saudi Arabia)

  • Emad M. Abdallah

    (Associate professor, Department of Laboratory Sciences, College of Sciences and Arts, Qassim University, Al-Rass, Saudi Arabia)

Abstract

The Pd-precatalyst was found to exhibit high catalytic activity for C-C bond formation in Suzuki-Miyaura cross-coupling reactions of differentheteroaryl (5-bromo-2-bromoacetyl) thiophene,4- (5-bromothiophen-2-yl)-methyl-1,3-thiazole,isoquinolinium bromide salt) with either aryl or heteroarylboronic acids. All reactions in this study were conducted in water under thermal heating as well as microwave irradiation conditions. The antimicrobial activities of synthesized compounds were evaluated against eight different strains of microorganisms (four fungal strains, two Gram-positive bacteria and two Gram-negative bacteria) using a cup plate diffusion method. The results showed that, most of the 20 tested compounds exhibited varying degrees of antimicrobial activities. However, 6 compounds recorded high antifungal activity (? 20 mm zone of inhibition), 3 were antibacterial (against Gram-positive) and 4 showed high broad-spectrum antibacterial efficacy (against Gram-positive and Gram-negative). These bioactive compounds are recommended for further pharmacological and toxicological investigations for possible formulation as wide spectrum antibacterial and antifungal agents.

Suggested Citation

  • Manahil B. Elamin* & Shazalia M. Ali & Emad M. Abdallah, 2018. "Antimicrobial Evaluation of New Synthesized Aza Heterocycles," Academic Journal of Chemistry, Academic Research Publishing Group, vol. 3(9), pages 78-87, 09-2018.
    • Handle: RePEc:arp:ajcarp:2018:p:78-87
    DOI: 10.32861/ajc.39.78.87
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