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Expression of Vascular Endothelial Growth Factor (VEGF) in Juvenile Nasopharyngeal Angiofibroma in Haji Adam Malik General Hospital Medan

Author

Listed:
  • Yuli Tetriana Sari

    (Otorhinolaryngology Head and Neck Surgery Departement, Universitas Sumatera Utara / H. Adam Malik General Hospital, Medan, Indonesia)

  • Rizalina A. Asnir

    (Otorhinolaryngology Head and Neck Surgery Departement, Universitas Sumatera Utara / H. Adam Malik General Hospital, Medan, Indonesia)

  • Ashri Yudhistira

    (Otorhinolaryngology Head and Neck Surgery Departement, Universitas Sumatera Utara / H. Adam Malik General Hospital, Medan, Indonesia)

  • Sutoyo Elliandy

    (Pathological Anatomy Unit Installation, H. Adam Malik Medan General Hospital)

Abstract

Juvenile Nasopharyngeal Angiofibroma (JNA) is a benign blood vessel tumor that is locally aggressive in young adults. VEGF is an important growth factor in tumor biology. VEGF overexpression has been associated with tumor progression and poor prognosis in various types of tumors. VEGF expression in angiofibroma has been previously noted and associated with proliferation and increasing blood vessel density. To determine the expression of Vascular Endothelial Growth Factor (VEGF) in JNA. A descriptive research with cross-sectional study design, the data was taken from medical records at the H. Adam Malik general hospital Medan from Januari 2011 to December 2017 with a total sample 24. Inclusion criteria included a sticky medical record and clear identify and had paraffin blocks with a JNA diagnosis. VEGF overexpression was found in 14 male patients (60.9%), and 11 people (61.1%) out of 18 people under the age of 20 years. In stage III, VEGF overexpression was found to be 90% and at stage IV reached 100%. VEGF overexpression in JNA was found especially at advanced stages.

Suggested Citation

  • Yuli Tetriana Sari & Rizalina A. Asnir & Ashri Yudhistira & Sutoyo Elliandy, 2018. "Expression of Vascular Endothelial Growth Factor (VEGF) in Juvenile Nasopharyngeal Angiofibroma in Haji Adam Malik General Hospital Medan," International Journal of Health and Medical Sciences, Mohammad A. H. Khan, vol. 4(3), pages 72-76.
    • Handle: RePEc:apa:ijhmss:2018:p:72-76
    DOI: 10.20469/ijhms.4.30003-3
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    Keywords

    JNA; VEGF; immunohistochemistry;
    All these keywords.

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