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Benzopyran-Core as an Antimycobacterial Agent

Author

Listed:
  • Sandile B Simelane

    (Department of Chemistry, Faculty of Science and Engineering, University of Eswatini, Eswatini)

  • Paseka T Moshapo

    (Department of Chemical Sciences, University of Johannesburg, South Africa)

  • Raban W Masuka

    (University of Zimbabwe, School of Pharmacy, Mt Pleasant Drive, Zimbabwe)

Abstract

Tuberculosis (TB) is one of the world’s most deadly infectious diseases, causing 1.2 million deaths in 2018. TB is the leading cause of death from a single infectious agent, ahead of HIV/AIDS. The African continent bears the highest global TB/HIV burden and over 50% of TB cases in sub-Saharan Africa are co-infected with HIV. With an estimated 1.7 billion people (23% of the world’s population) with latent TB infection, there is an urgent need to develop drugs that will eradicate or control the disease. Moreover, the emergence of multi-drug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) have accelerated the need for new antitubercular agents with novel biological targets and different mechanism of action. Among the wide spectra of heterocyclic compounds, benzopyran derivatives have displayed diverse biological applications.

Suggested Citation

  • Sandile B Simelane & Paseka T Moshapo & Raban W Masuka, 2020. "Benzopyran-Core as an Antimycobacterial Agent," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 10(2), pages 56-72, December.
    • Handle: RePEc:adp:jomcij:v:10:y:2020:i:2:p:56-72
    DOI: 10.19080/OMCIJ.2020.10.555784
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