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Enzyme Inhibition and In Silico Studies of New Synthetic N-Substituted- (4-Bromophenyl)-4-Ethoxybenzenesulfonamides

Author

Listed:
  • Naheed Riaz
  • Muhammad Iftikhar
  • Muhammad Saleem
  • Shahnawaz

    (Department of Chemistry, The Islamia University of Bahawalpur, Pakistan)

  • Aziz ur Rehman

    (Department of Chemistry, Government College University, Lahore, Pakistan)

  • Ishtiaq Ahmed

    (Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG-1), Hermann-von-Helmholtz-Platz, Karlsruhe, Germany)

  • Safdar Hussain
  • Muhammad Ashraf
  • Zahid Nawaz
  • Jameel Rahman
  • Mariya al Rashida

    (Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan)

Abstract

The sulfonamides (-SO2NH-) are proven as fascinating compounds as a main core for different bioactivities and can be more like a string of distinguished pearls. Sulfonamides are called sulfa drugs, which were the first antibacterial agents to be used systemically and paved the way for the antibiotic revolution in medicine. The first medicine of this class was Prontosil discovered as effective treatment of a range of bacterial infections. It had strong protective action against infections caused by Streptococci, including blood infections, childbed fever, and erysipelas [1].

Suggested Citation

  • Naheed Riaz & Muhammad Iftikhar & Muhammad Saleem & Shahnawaz & Aziz ur Rehman & Ishtiaq Ahmed & Safdar Hussain & Muhammad Ashraf & Zahid Nawaz & Jameel Rahman & Mariya al Rashida, 2020. "Enzyme Inhibition and In Silico Studies of New Synthetic N-Substituted- (4-Bromophenyl)-4-Ethoxybenzenesulfonamides," Organic & Medicinal Chemistry International Journal, Juniper Publishers Inc., vol. 10(2), pages 46-55, December.
    • Handle: RePEc:adp:jomcij:v:10:y:2020:i:2:p:46-55
    DOI: 10.19080/OMCIJ.2020.10.555783
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