Anti-Microbial Properties of C-benzylated Dihydro Chalcone Derivatives: 2’, 4’-Dihydroxy-3’,5’-( 2’’, 2’’’- Dihydroxy Dibenzyl) - 6’-Methoxy Dihydro Chalcone, 2’,4’-Dihydroxy-3’- ( 2’’- Hydroxy Benzyl) –6’- Methyl Dihydrochalcone and 2’, 4’, 6’ – Tri Hydroxy- 3’- ( 2’’-Hydroxy Benzyl) Dihydro Chalcone Isolated from Stem Bark of Uvaria Chamae P. Beav

Two new C- benzylated dihydro chalcones derivatives:, 2’, 4’- dihydroxy- 3’ – (2†, - hydroxyl benzyl)- 6’ –methyl dihydro chalcone , 2’, 4’, 6’- trihydroxy-3’- (2’’ – hydroxy benzyl) dihydro chalcones and a known compound, 2’, 4’- dihydroxy-3’, 5’ – (2’’. 2†’ –dihydroxy benzyl) – 6’- methoxy dihydro chalcone (diuvaretin) were isolated from the stem-bark of Uvaria chamae. The structures of the compounds were elucidated by spectroscopic methods: FTIR, 1HNMR, 13CNMR as well as by comparison with literature data. The isolated compounds were evaluated for their antibacterial and antifungal activities using Disc diffusion method. All the three compounds exhibited high activities against all the tested microbes with diuvaretin exhibiting the highest activities with inhibition zones ranging from 12-30 mm, for bacterial and 14-30mm for fungal organisms, at the highest concentration of 1000μg/cm3. Therefore, U. chamae contain promising antimicrobial compounds with diverse biological activities that can be used in developing drugs for curing life threatening diseases caused by the tested organisms such as typhoid fever, darriahoea and aflotoxins caused by molds.