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Protective Effect of Apple Polyphenols on Acute Ethanol-Induced Neurobehavioral Damage in Mice

Author

Listed:
  • Fang Wang
  • Lu Li

    (School of Functional Food and Wine, Shenyang Pharmaceutical University, China
    Engineering Research Center for Research and Development of Plant Polyphenols of Liaoning Province, China)

  • Haifeng Zhang
  • Xianchu Han
  • Yanxia Fan
  • Mingming Liu
  • Zhenzhen Song

    (Department of Pharmacology, Shenyang Pharmaceutical University, China)

  • Jingyu Yang

    (Engineering Research Center for Research and Development of Plant Polyphenols of Liaoning Province, China
    Department of Pharmacology, Shenyang Pharmaceutical University, China)

  • Chunfu Wu

    (Engineering Research Center for Research and Development of Plant Polyphenols of Liaoning Province, China
    Department of Pharmacology, Shenyang Pharmaceutical University, China)

Abstract

The present study was to determine the protective effect of apple polyphenols on acute ethanol-induced neurobehavioral damages in mice as well as its possible mechanism of action. A loss of righting reflex test in mice was used to study the protective effect of apple polyphenols on the hypnotic effect caused by acute ethanol intake (4.0g/kg, i.p). Rotarod performance test in mice was used to study the protective effect of apple polyphenols on motor ataxia caused by acute ethanol intake (2.4g/kg, i.p). Blood ethanol concentration and alcohol dehydrogenase activity were measured using assay kits. Pretreatment with apple polyphenols (400 and 800mg/kg) for 1, 3, and 7 days significantly shortened acute ethanol-induced duration of righting reflex loss in Loss of Righting Reflex Test. Pretreatment with apple polyphenols (200mg/kg) for 3 and 7 days and apple polyphenols (200, 400 and 800mg/kg) for 1, 3, and 7 days significantly prolonged the latency to fall off the rotarod after acute ethanol injection in rotarod performance test. All doses of apple polyphenols decreased blood ethanol concentration while apple polyphenols (800mg/kg) increased hepatic alcohol dehydrogenase activity after acute ethanol injection. These results indicate that apple polyphenols have significant protective effects against the hypnotic effect and motor ataxia induced by acute ethanol. These effects may partially occur via a mechanism linked to promoting ethanol metabolism.

Suggested Citation

  • Fang Wang & Lu Li & Haifeng Zhang & Xianchu Han & Yanxia Fan & Mingming Liu & Zhenzhen Song & Jingyu Yang & Chunfu Wu, 2019. "Protective Effect of Apple Polyphenols on Acute Ethanol-Induced Neurobehavioral Damage in Mice," Nutrition & Food Science International Journal, Juniper Publishers Inc., vol. 8(2), pages 37-42, January.
    • Handle: RePEc:adp:jnfsij:v:8:y:2019:i:2:p:37-42
    DOI: 10.19081/NFSIJ.2019.08.555733
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