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Polyol Pathway Shed Light on Non-Obstructive Azoospermia Testicular Sperm Extraction (TESE) Negative ROS Imbalance

Author

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  • Kambiz Gilany

    (Reproductive Biotechnology Research Center, Avicenna Research Institute, Iran
    Metabolomics and Genomics Research Center, Endocrinology and Metabolomics Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Iran)

Abstract

In our recent study regarding non-obstructive azoospermia by metabolomics technology, we clearly demonstrated that testicular sperm extraction negative patients are in extreme oxidative imbalance. With a reanalysis of our data and the integration of proteomics data, we found the Polyol pathway is up-regulated in non-obstructive azoospermia testicular sperm extraction negative patients. In this regard, we suggest the contribution of this biochemical pathway in the extreme oxidative imbalance of non-obstructive azoospermia testicular sperm extraction negative patients.

Suggested Citation

  • Kambiz Gilany, 2018. "Polyol Pathway Shed Light on Non-Obstructive Azoospermia Testicular Sperm Extraction (TESE) Negative ROS Imbalance," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 5(5), pages 96-97, August.
    • Handle: RePEc:adp:jgjorm:v:5:y:2018:i:5:p:96-97
    DOI: 10.19080/GJORM.2018.05.555675
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