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Could We Hack Women’s Biological Clock? A Mitochondrial Hypothesis

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  • Ana T Marcos
  • Jose M Navarro-Pando

    (Department of Genetics, Instituto para el Estudio de la Biología de la Reproducción Humana INEBIR, Seville, Spain)

Abstract

Our knowledge about aging infertility suggests that oocyte quality is the major contributing factor. Assisted reproductive technologies (ART) teach us two critical facts about this topic: the reduction of reproductive capacity observed in aged women is related with the oocyte´s age, and how we can reverse the aging process getting high rates of live-birth pregnancies achieved by aged women with oocytes donated by younger women. The biologic reason why older women have a lower pregnancy rate is because aneuploid embryos are more frequently obtained from aged women. In this context, the quality of oocyte mitochondria is determinant in embryo quality, relating to euploid embryos, since mitotic non-disjunction occurs more frequently in advanced aged women [1].

Suggested Citation

  • Ana T Marcos & Jose M Navarro-Pando, 2018. "Could We Hack Women’s Biological Clock? A Mitochondrial Hypothesis," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 3(2), pages 33-35, February.
    • Handle: RePEc:adp:jgjorm:v:3:y:2018:i:2:p:33-35
    DOI: 10.19080/GJORM.2018.03.555608
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    References listed on IDEAS

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    1. Lyndsey Craven & Helen A. Tuppen & Gareth D. Greggains & Stephen J. Harbottle & Julie L. Murphy & Lynsey M. Cree & Alison P. Murdoch & Patrick F. Chinnery & Robert W. Taylor & Robert N. Lightowlers & , 2010. "Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease," Nature, Nature, vol. 465(7294), pages 82-85, May.
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