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Dienogest in the Treatment of Endometriosis

Author

Listed:
  • Kazushige Adachi
  • Akiko Otake
  • Yoshimitsu Yamamoto

    (Department of Obstetrics and Gynecology, Minoh City Hospital, Japan)

Abstract

Endometriosis is a prevalent chronic disease in up to 10% of women of reproductive age and often causes pain symptoms. In some patients, these symptoms negatively affect quality of life for a long time. Dienogest is an oral progestin that was recently approved for the treatment of endometriosis. It is allowed for long-term administration with a favorable safety and tolerability profile. Dienogest 2mg/day was superior to placebo in relieving pain symptoms in patients with endometriosis, equivalently effective to gonadotropin releasing hormone agonist (GnRHa). The size of endometriomas was reduced by use of dienogest. Postoperative administration of dienogest showed the efficacy in relieving pain and suppressing recurrence of endometrioma in patients with endometriosis. Dienogest was also effective in relieving symptoms in women with deep infiltrating endometriosis (DIE) or extragenital endometriosis. Dienogest is an alternative for the treatment of endometriosis because of its efficacy, safety and tolerability.

Suggested Citation

  • Kazushige Adachi & Akiko Otake & Yoshimitsu Yamamoto, 2017. "Dienogest in the Treatment of Endometriosis," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 2(3), pages 41-43, Seprember.
    • Handle: RePEc:adp:jgjorm:v:2:y:2017:i:3:p:41-43
    DOI: 10.19080/GJORM.2017.02.555586
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