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Clomiphene Citrate and Oocyte Quality

Author

Listed:
  • Shail K Chaube
  • Meenakshi Tiwari
  • Anumegha Gupta
  • Alka Sharma
  • Shilpa Prasad
  • Ashutosh N Pandey
  • Pramod K Yadav
  • Sabana Khatun

    (Department of Zoology, Institute of science Banaras Hindu University, Varanasi-221005, India)

  • Tulsidas G Shrivastav

    (Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Delhi-110067,India)

Abstract

The clomiphene citrate (CC) is a first line of medicine used for ovulation induction in women worldwide. CC has good ovulation induction ability in anovulatory women but the pregnancy rate is very poor. This discrepancy might be due to the anti-estrogenic effect of CC at various level including ovary and oocytes. The hypoestrogenic conditions due to CC treatment inhibit follicular growth and development, induce susceptibility of oocytes towards apoptosis and deteriorate oocyte quality after ovulation. CC induces reactive oxygen species (ROS) mediated granulosa cells as well as oocyte apoptosis within the follicle of the ovary. Apoptosis deteriorates oocyte quality and thereby reproductive outcome. Supplementation of estradiol 17β or natural antioxidant such as melatonin prevents anti-estrogenic effects of CC and improves oocyte quality by scavenging CC induced generation of ROS. Thus, we propose that the supplementation of estradiol 17β and/or melatonin along with CC may be beneficial to overcome the anti-estrogenic effect of CC during infertility management in human.

Suggested Citation

  • Shail K Chaube & Meenakshi Tiwari & Anumegha Gupta & Alka Sharma & Shilpa Prasad & Ashutosh N Pandey & Pramod K Yadav & Sabana Khatun & Tulsidas G Shrivastav, 2017. "Clomiphene Citrate and Oocyte Quality," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 1(4), pages 91-93, July.
    • Handle: RePEc:adp:jgjorm:v:1:y:2017:i:4:p:91-93
    DOI: 10.19080/GJORM.2017.01.555570
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