IDEAS home Printed from https://ideas.repec.org/a/adp/jctoij/v9y2018i5p13-16.html
   My bibliography  Save this article

Two Decades of (Mostly) Disappointments in Definitive Chemoradiation for Stage III Non-Small Cell Lung Cancer

Author

Listed:
  • John H Park

    (Kansas City VA Medical Center, USA)

Abstract

The past two decades have little to show in the progress of definitive chemoradiation for stage III lung cancer patients. Radiation dose escalation, elective nodal irradiation, prophylactic cranial irradiation, and proton therapy have not shown to improve outcomes. The addition of surgery to the backbone of concurrent chemoradiation has also shown no benefit, except possibly in patients who can undergo a lobectomy. Consolidative chemotherapy, adjuvant gefitinib, induction chemotherapy, pemetrexed for non-squamous histologies, and the addition of cetuximab have also all failed in terms of systemic therapy. Progress has been made only recently with the addition of adjuvant durvalumab, a PD-L1 inhibitor, which significantly improved outcomes in this population and now is part of the standard of care.

Suggested Citation

  • John H Park, 2018. "Two Decades of (Mostly) Disappointments in Definitive Chemoradiation for Stage III Non-Small Cell Lung Cancer," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 9(5), pages 13-16, April.
    • Handle: RePEc:adp:jctoij:v:9:y:2018:i:5:p:13-16
    DOI: 10.19080/CTOIJ.2018.09.555780
    as

    Download full text from publisher

    File URL: https://juniperpublishers.com/ctoij/pdf/CTOIJ.MS.ID.555780.pdf
    Download Restriction: no
    File URL: https://juniperpublishers.com/ctoij/CTOIJ.MS.ID.555780.php
    Download Restriction: no
    File URL: https://libkey.io/10.19080/CTOIJ.2018.09.555780?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adp:jctoij:v:9:y:2018:i:5:p:13-16. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Robert Thomas (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.