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Gene Routes in Colorectal Cancer

Author

Listed:
  • Asif Meraj
  • Mudassir khan
  • Rauf Wani

    (General & Minimal Invasive Surgery, Sher-i-Kashmir Institute of Medical sciences, India)

Abstract

Colorectal cancer results from an accumulation of genetic abnormalities in the nuclei of colonic cells that allow the cells to escape the normal controls on cellular growth, death, and differentiation. The causes of these genetic abnormalities include mutations that happen during various phases of cell division, elements of life-style, personal characteristics, and inheritance. Each colorectal cancer is genetically unique, with hundreds of different mutated genes. However, the number of genes which when mutated drive carcinogenesis forward is limited [1]. Despite the genetic heterogeneity displayed in colorectal cancers there are three main routes (Figure 1) through which colorectal cancer develops [2]. These three routes produce cancers of different biology. It is important to distinguish between the routes, because the differences in biology have different clinical implications.

Suggested Citation

  • Asif Meraj & Mudassir khan & Rauf Wani, 2018. "Gene Routes in Colorectal Cancer," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 9(4), pages 126-129, March.
    • Handle: RePEc:adp:jctoij:v:9:y:2018:i:4:p:126-129
    DOI: 10.19080/CTOIJ.2018.09.555772
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