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Cellular Modeling of Cancer Therapy Induced Cardiotoxicity

Author

Listed:
  • William P Bozza
  • Keisha Melodi McSweeney
  • Baolin Zhang

    (Center for Drug Evaluation and Research, Food and Drug Administration, USA)

Abstract

Drug-induced cardiotoxicity is a major safety concern in cancer therapy. Cytotoxic agents and targeted therapies used to treat cancer, including classic chemotherapeutic agents, monoclonal antibodies that target tyrosine kinase receptors, small molecule tyrosine kinase inhibitors, and even antiangiogenic drugs, all affect the cardiovascular system. Examples of clinical cardiotoxic side effects include reduction of left ventricular ejection fraction, arrhythmia, cardiomyopathy, myocarditis, heart failure, and even cardiac death [1,2]. The current clinical surveillance and monitoring approaches for cardiac dysfunction during cancer

Suggested Citation

  • William P Bozza & Keisha Melodi McSweeney & Baolin Zhang, 2018. "Cellular Modeling of Cancer Therapy Induced Cardiotoxicity," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 9(1), pages 1-4, January.
    • Handle: RePEc:adp:jctoij:v:9:y:2018:i:1:p:1-4
    DOI: 10.19080/CTOIJ.2018.09.555751
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