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Free Radical Scavenging and Cytotoxic Activities of Substituted Pyrimidines

Author

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  • Qurat-ul-Ain

    (Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi Pakistan)

Abstract

A library of substituted pyrimidines was synthesized and evaluated for free radical scavenging, and in vitro cytotoxic activity in 3T3 cells. All compounds showed good free radical scavenging activity with IC50 values in the range of 42.9 ± 0.31 to 438.3 ± 3.3 μM as compared to the standard butylated hydroxytoluene having IC50 value of 128.83 ± 2. 1 μM. The structure activity-relationship was also established. Selected analogues 1, 2, 3, 5, 6, 7, 8, 9, 10, 12, 13, 15, 19, 20, 21, 24, 25, 26 and 28 were tested for cytotoxicity in mouse fibroblast 3T3 cell line using MTT assay, and most of the analogues showed cytotoxicity. This study has identified a number of cytotoxic novel substituted pyrimidines having free radical scavenging activities that can be used as inhibitory compounds for those cancer cells whose growth is mediated by reactive oxygen species.

Suggested Citation

  • Qurat-ul-Ain, 2020. "Free Radical Scavenging and Cytotoxic Activities of Substituted Pyrimidines," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 16(3), pages 52-60, June.
    • Handle: RePEc:adp:jctoij:v:16:y:2020:i:3:p:52-60
    DOI: 10.19080/CTOIJ.2020.16.555940
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