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Potential Movement of CDK 4/6 Inhibitor from Cell Cycle Arrest to Immune Activation in Breast Cancer

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  • Pamungkas Bagus Satriyo

    (International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan
    Doctoral Program of Medical Science and Health, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia)

Abstract

Three different CDK 4/6 inhibitor was approved in a short time during 2016-2017 by FDA to treat hormone receptor-positive (HR+), HER2 negative (-) advances breast cancer patients. Since the beginning of the preclinical study, palbociclib, ribociclib, and abemaciclib were markedly suppressed proliferations of HR+/HER2- cell lines but less effective to HER2+ and Triple Negative Breast Cancer. This suppression mechanism acts through the CKD4/6-Rb-E2F axis.

Suggested Citation

  • Pamungkas Bagus Satriyo, 2019. "Potential Movement of CDK 4/6 Inhibitor from Cell Cycle Arrest to Immune Activation in Breast Cancer," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 13(1), pages 52-54, February.
    • Handle: RePEc:adp:jctoij:v:13:y:2019:i:1:p:52-54
    DOI: 10.19080/CTOIJ.2019.13.555855
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