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Hybrid Approach of Hyperthermia and Controlled Drug Delivery in Cancer: Image Guided Cancer Theranostic Monitoring in Tumor Management

Author

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  • Rakesh Sharma

    (Innovations and Solutions Inc, Florida State University Research Foundation, USA
    Department of Medicine, Columbia University, USA)

Abstract

Nonpathogenic bacteria coats filled with complex metal nanoparticles form multifunctional magnetic nanoparticles (MNPs) for targeting cancer tumors. The encapsulated metal nanoparticles along with anticancer drugs inside polymer or bacterial coats become physiologically tumor sensitive due to hysteresis and pH sensitivity and drug active covalent bonds. Drug-bearing bacterial and polymer nanoshells open and close at specific pH to release anticancer drugs in controlled manner at the tumor sites. Simultaneously, metal core generates multimodal images. Such combined effect of chemotherapy and tumor sensitive nanodrugs offers hybrid approach of an effective and minimal invasive protocol of tumor management.

Suggested Citation

  • Rakesh Sharma, 2018. "Hybrid Approach of Hyperthermia and Controlled Drug Delivery in Cancer: Image Guided Cancer Theranostic Monitoring in Tumor Management," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 11(1), pages 16-27, May.
  • Handle: RePEc:adp:jctoij:v:11:y:2018:i:1:p:16-27
    DOI: 10.19080/CTOIJ.2018.11.555803
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