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Molecular Docking, Synthesis, in Silico and in vitro Screening of Substituted Aryl Ureido Analogues as BACE1 Inhibitors to target Alzheimer’s Disease

Author

Listed:
  • Archana S Gurjar

    (Department of Pharmaceutical Chemistry, India)

  • Vinay Velingkar

    (HK College of Pharmacy, India)

  • Vincenza Andrisano
  • Angela D Simone

    (Department for Life Quality Studies, India)

Abstract

BACE1 plays critical role in the formation of neurotoxic β-amyloid (Aβ) peptides in brain and so is regarded as an ideal drug design target for Alzheimer’s disease...

Suggested Citation

  • Archana S Gurjar & Vinay Velingkar & Vincenza Andrisano & Angela D Simone, 2018. "Molecular Docking, Synthesis, in Silico and in vitro Screening of Substituted Aryl Ureido Analogues as BACE1 Inhibitors to target Alzheimer’s Disease," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 11(4), pages 8679-8684, December.
    • Handle: RePEc:abf:journl:v:11:y:2018:i:4:p:8679-8684
    DOI: 10.26717/BJSTR.2018.11.002140
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    More about this item

    Keywords

    Biomedical Sciences; Biomedical Research; Technical Research; BACE1; Aryl Ureido Analogues; Molecular Docking; in Silico ADME; In Vitro; FRET Assay;
    All these keywords.

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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